Pdcd1lg2 Rat Monoclonal Antibody [Clone ID: TY25]
Specifications
| Product Data | |
| Clone Name | TY25 |
|---|---|
| Application | FC |
| Recommended Dilution | Flow cytometry (Neat - 1/5): use 10 µl of the suggested working dilution to label 106 cells in 100 µl. |
| Reactivity | Mouse |
| Antibody Host | Rat |
| Isotype | IgG2a |
| Clonality | Monoclonal |
| Immunogen | B7-DC transfected RAW264.7 cells. Lymph node cells from immunised SD rats were fused with the cells of the P3U1 myeloma cell line. |
| Specificity | This antibody clone TY25 recognizes Mouse CD273. This clone TY25 is reported to block the binding of CD273 (B7-DC) to it's receptor (Matsumoto et al. 2004). Removal of sodium azide is recommended prior to use in functional assays. |
| Buffer | PBS, pH 7.4 containing 0.09% Sodium Azide and 1% BSA Label: FITC State: Liquid purified IgG fraction Label: Fluorescein Isothiocyanate Isomer 1 |
| Concentration | lot specific |
| Purification | Affinity chromatography on Protein G |
| Conjugation | FITC |
| Storage | Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. This product is photosensitive and should be protected from light. |
| Stability | Shelf life: one year from despatch. |
| Shipping | Blue Ice |
| Gene Name | programmed cell death 1 ligand 2 |
| Database Link | |
| Background | CD273 is a member of the B7 family, otherwise known as B7-dendritic cell (B7-DC), or programmed death ligand-2 (PD-L2). The expression of CD273 is restricted to a subpopulation of dendritic cells (DCs), and DCs and macrophages that have been stimulated with interferon gamma, GM-CSF or IL-4. CD273 has been identified as a ligand for PD-1(CD279), along with another B7 family member B7-H1 (CD279). Studies suggest that both CD273 and B7-H1 co-stimulate or inhibit T cell proliferation and cytokine production. |
| Synonyms | PD-L2, PD-1-ligand 2, PDCD1 ligand 2, PDCD1LG2, B7DC, PDCD1L2 |
| Reference Data | |
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