TNFSF4 Mouse Monoclonal Antibody [Clone ID: 7D6]
Specifications
| Product Data | |
| Clone Name | 7D6 |
|---|---|
| Application | FC, WB |
| Recommended Dilution | Flow Cytometery. Western Blot: 1.0 ug/ml; the antibody detects a band of approximately 43 kDa. |
| Reactivity | Feline |
| Antibody Host | Mouse |
| Isotype | IgG1 |
| Clonality | Monoclonal |
| Immunogen | CHO-derived feline CD134-Fc fusion protein. Spleen cells from immunised Balb/c mice were fused with cells of the NSO mouse myeloma cell line. |
| Specificity | This antibody recognises feline CD134, otherwise known as OX40, a 43kDa type I membrane protein and member of the tumor necrosis factor receptor superfamily. |
| Buffer | PBS containing 0.09% Sodium Azide as preservative. State: Purified State: Liquid purified Ig fraction. |
| Concentration | lot specific |
| Purification | Affinity chromatography on Protein A. |
| Conjugation | Unconjugated |
| Storage | Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. |
| Stability | Shelf life: one year from despatch. |
| Shipping | Blue Ice |
| Database Link | |
| Background | This antigen is expressed predominantly by CD4+ activated T cells, and a key regulator of T cell-dependent immune responses. CD134 has been identified as the receptor for the OX40 ligand, CD252, expressed by activated B cells, acting as a co-stimulatory signal for the stimulation and secretion of immunoglobulins. CD134 has also been identified as a binding receptor for Feline Immunodeficiency Virus (FIV), acting along with CXC chemokine receptor 4 (CXCR4) to facilitate the entry of the virus into CD4+ primary target cells. |
| Synonyms | TNFRSF4, TXGP1L, ACT35 antigen, OX40L receptor |
| Reference Data | |
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