HCV Core protein Genotype 1a+2 Mouse Monoclonal Antibody [Clone ID: B055M]
$1,765.00
2 Weeks*
Specifications
| Product Data | |
| Clone Name | B055M |
|---|---|
| Application | ELISA |
| Recommended Dilution | ELISA. Does not work in Western Blot or IFA. |
| Reactivity | Hepatitis C Virus |
| Antibody Host | Mouse |
| Isotype | IgG2a |
| Clonality | Monoclonal |
| Immunogen | Recombinant HCV core antigen, genotype 1a |
| Specificity | This antibody reacts to Hepatitis C Virus (HCV) Core Antigen. Reactive with genotypes 1a and 2. |
| Buffer | 0.01M PBS, pH 7.2 containing 0.09% sodium azide State: Purified State: Liquid purified IgG fraction (> 90% pure) Stabilizer: None |
| Concentration | lot specific |
| Purification | Protein A Chromatography |
| Conjugation | Unconjugated |
| Storage | Upon receipt, store undiluted (in aliquots) at -20°C. Avoid repeated freezing and thawing. |
| Stability | Shelf life: one year from despatch. |
| Shipping | Blue Ice |
| Background | The hepatitis C virus (HCV) core protein represents the first 191 amino acids of the viral precursor polyprotein and is cotranslationally inserted into the membrane of the endoplasmic reticulum. Hepatitis C virus (HCV) core is a viral structural protein; it also participates in some cellular processes, including transcriptional regulation. However the mechanisms of core-mediated transcriptional regulation remain poorly understood. Hepatitis C virus (HCV) core protein is thought to contribute to HCV pathogenesis through its interaction with various signal transduction pathways. In addition, HCV core antigen is a recently developed marker of hepatitis C infection. The HCV core protein has been previously shown to circulate in the bloodstream of HCV-infected patients and inhibit host immunity through an interaction with gC1qR. Hepatitis C Virus is a positive, single stranded RNA virus in the Flaviviridae family. The genome is approximately 10,000 nucleotides and encodes a single polyprotein of about 3,000 amino acids. The polyprotein is processed by host cell and viral proteases into three major structural proteins and several non structural proteins necessary for viral replication. Hepatitis C virus (HCV) causes most cases of non-A, non-B hepatitis and results in most HCV infected people developing chronic infections, liver cirrhosis and hepatocellular carcinoma. T cell responses, including interferon-gamma production are severely suppressed in chronic HCV patients. |
| Synonyms | Hepatitis C Virus core protein |
| Reference Data | |
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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen
complexities in the preparation of your product. International customers may expect an additional 1-2 weeks
in shipping.