Jul 11, 2022
Interleukin 6 (IL-6) is a pleiotropic cytokine. It plays important role in inflammation disorders, autoimmune diseases, obesity, and cancer. Levels of IL-6 in human blood are very low under normal conditions, but the levels can increase thousands-fold in inflammatory states. Thus, monitoring IL-6 levels can help in diagnosing and preventing infectious diseases.
IL-6 Signaling Pathway
IL-6 has both pro-and anti-inflammatory functions that are mediated by the soluble form of IL-6 receptor (sIL-6R; trans-signaling) and the membrane-bound IL-6R (classic signaling). Ligand-bound IL-6 receptors can assemble with the integral protein gp130 (IL6ST) to recruit non-receptor tyrosine kinases (e.g., JAK1) and activate STAT3.
IL-6 Resource Tool Center
Assay Kits for IL6Get your IL-6 Elisa Kit here
Antibodies for IL6
OriGene has developed highly-specific and sensitive antibodies that recognize native epitopes which can be used in IHC, ELISA, WB. IF, IP etc
IHC staining of paraffin-embedded Human endometrium tissue within the normal limits using anti-IL-6 mouse monoclonal antibody.
IHC staining of paraffin-embedded Human pancreas tissue within the normal limits using anti-IL-6 mouse monoclonal antibody.
Primary Antibody Samples
IHC staining of paraffin-embedded Human prostate tissue within the normal limits using anti-IL-6 mouse monoclonal antibody.
Clones for IL6
OriGene has developed expression ready plasmids and Lentiviral particles for various species such as human, mouse and rat species.