An emerging biomarker for neurological disorders

Aug 25, 2022

Why is GFAP important?

GFAP (Glial Fibrillary Acidic Protein) is a type III intermediate filament protein that is expressed by numerous cell types in the central nervous system (CNS), including astrocytes and ependymal cells during development.

GFAP has been shown to be important in the pathogenesis of Alexander disease and in repair after CNS injury. Evidence suggests that minor changes in blood GFAP levels are associated with subtle injuries to the CNS. Decreases in GFAP expression have been reported in Down's syndrome, schizophrenia, bipolar disorder, and depression.

Serum GFAP shows promise as a biomarker of disease severity in frontotemporal lobar degeneration (FTLD) and might be a suitable multiple sclerosis progression biomarkers. In addition, few studies have explored the possibility of blood GFAP levels as a biomarker for traumatic spinal cord injury. 

GFAP Resource Tool Center

Assay Kits for GFAP

OriGene's GFAP ELISA kit provides sensitive and reliable GFAP measurements to obtain valuable data from your experiments.

Get your GFAP Elisa Kit here

GFAP Standard Curve

Antibodies for GFAP

OriGene has developed highly-specific and sensitive antibodies that recognize native epitopes which can be used in IHC, ELISA, WB. IF, IP etc

Mono-specific Antibodies

UM500005

Immunohistochemical staining of paraffin-embedded Human embryonic brain tissue using anti-GFAP mouse monoclonal antibody.

Cat# UM500005

Carrier-Free Antibodies

CF500337

Immunohistochemical staining of paraffin-embedded Human embryonic brain cortex tissue within the normal limits using anti-GFAP mouse monoclonal antibody.

Cat# CF500337

Primary Antibody Samples

TA500338S

Immunohistochemical staining of paraffin-embedded lymph node tissue using anti-GFAP mouse monoclonal antibody.

Cat# TA500338S

Anti-GFAP Antibodies

Clones for GFAP

OriGene has developed expression ready plasmids and Lentiviral particles for various species such as human, mouse and rat species

Tagged/Un-Tagged Clones

RC204548

HEK293T cells were transfected with the pCMV6-ENTRY control (Cat# PS100001, Left lane) or pCMV6-ENTRY GFAP (Cat# RC204548, Right lane) cDNA for 48 hrs and lysed

Cat# RC204548

Lentiviral Particles

RC204548L1

Double digestion of RC204548L1 using SgfI and MluI

Cat# RC204548L1

Other products for GFAP