Posts for 12/2023


ASOs vs siRNA – Which is Right for Me?

Dec 21, 2023

Antisense Oligonucleotides (ASOs) and small interfering RNAs (siRNAs) emerge as pivotal tools in molecular biology, offering precise means to silence targeted genes. In this blog we will explore the intricacies of these powerful gene-silencing tools, delving into their mechanisms and key differences. What are Antisense Oligonucleotides? Antisense oligonucleotides (ASOs) are synthetic, single-stranded DNA or RNA molecules designed to bind selectively to complementary RNA sequences. On...

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Understanding Plasmid Multimers

Dec 12, 2023

Plasmids are small, circular, double-stranded DNA molecules found in bacteria and some other single-celled organisms like archaea. They exist separate from the chromosomal DNA and carry genes that are often advantageous but not essential for the host cell's survival. Purified plasmids serve as versatile tools in scientific research and practical applications. In research laboratories, they're pivotal for gene cloning, allowing scientists to deliver specific genes...

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Unlocking the secrets: A proven guide to mastering ELISA assay troubleshooting

Dec 01, 2023

ELISAs are widely used to quantify or detect antigens, hormones and antibodies. ELISA assays rely on an antibody that’s specific for the target of interest, and detection methods may be direct, two step, or rely on two types of antibodies (capture and detection). When running ELISAs it’s not unusual to encounter various types of assay issues. However, these issues result in reduced accuracy, increased variability,...

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