Posts for 11/2023


Lentivirus Biosafety: Ensuring Safe and Responsible Research

Nov 20, 2023

Lentiviruses have become indispensable tools in molecular biology, enabling precise gene delivery and manipulation. As researchers harness the potential of lentiviral vectors, it is paramount to prioritize biosafety. There have been considerable efforts to improve the safety of lentiviral vectors, thus 3 different generations exist, with increasing safety modifications. 2nd and 3rd generation systems are the most common vectors seen in the marketplace, thus knowing...

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Tips and Tricks for troubleshooting common western blot issues

Nov 17, 2023

Western blots are a ubiquitous technique used in research labs to study proteins of interest. Western blotting is used for antibody validation, protein-protein interaction studies, and many other applications.1 However, generating interpretable western blot results can be challenging. Below are some commonly encountered issues and how to resolve them.2 High Background Could be caused by Try this High antibody concentrationSet up a titration with both...

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CytoSections™ - Use case for antibody validation of the IDH1(R132H) mutation in Glioblastomas

Nov 09, 2023

Gliomas are the most frequent type of malignant brain tumor in adults, occuring in over 80% of cases.1 The enzyme isocitrate dehydrogenase, (IDH), plays a crucial role in regular metabolic processes and maintaining homeostasis. IDH mutations however, are characteristic of a specific group of diffuse gliomas.2 In particular, mutation of IDH1 is a key indicator for patient survival. Patients with secondary glioblastomas containing the IDH1(R132H)...

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