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Webinar on Cancer Biomarker
Cancer Biomarker Webinar

OriGene TissueScan in recent publications
A new subtype of bone sarcoma defined by BCOR-CCNB3 gene fusion Nature Genetics 44, 461-466 doi:10.1038/ng.1107 [Testis mRNA]
Mutation of A677 in histone methyltransferase EZH2 in human B-cell lymphoma promotes hypertrimethylation of histone H3 on lysine 27 (H3K27) PNAS, Feb 2012; 109: 2989 - 2994. [Primary Tissue and DNA Samples]
Circulating Adiponectin Is Inversely Associated with Risk of Thyroid Cancer: In Vivo and in Vitro Studies J. Clin. Endocrinol. Metab., Dec 2011; 96: E2023 - E2028. [four normal thyroid tissue specimens ]
QKI-Mediated Alternative Splicing of the Histone Variant MacroH2A1 Regulates Cancer Cell Proliferation Mol. Cell. Biol., Oct 2011; 31: 4244 - 4255. [Breast Tissue RNA]

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Advanced Tools for Cancer Biomarker Discovery and Validation

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As a gene-centric company, OriGene has developed unique technologies and products for cancer biomarker discovery and validation

  1. Most comprehensive human cancer tissue biorepository
    • >140,000 tissue collections
    • Collected under strict IRB and ethical consenting practices
    • Annotated with associated clinical data
  2. TissueScan Cancer cDNA arrays for qPCR – mRNA expression profiling
    • Panels of normalized cDNA prepared from tumor tissues, ready for qPCR
    • Broad tumor coverage – Multiple panels for breast, colon, lung, ovarian, and prostate cancers
    • Convenient and fast – qPCR ready format; results in less than 2 hours.
  3. ProteoScan Cancer Lysate Arrays – protein expression profiling
    • High-density reverse-phase protein arrays (RPPA) spotted with cancer and normal tissue lysates
    • 432 tissue lysates from pathologist-verified normal and cancer specimens
    • 11 cancers represented (25 cancer samples +15 normal samples per cancer type)
  4. Cancer-pathway specific qPCR primer Panels
    • 21 pre-designed key cancer pathways
    • qPCR screening-ready format
    • Custom panels available

 

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