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Home siRNA SR306706
NR1I3 (ID 9970) Trilencer-27 Human siRNA
| Catalog No. |
Description |
Price |
Availability* |
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| SR306706 |
- NR1I3 (Human) - 3 unique 27mer siRNA duplexes - 2 nmol each (Locus ID 9970)
- Included - SR30004, Trilencer-27 Universal Scrambled Negative Control siRNA Duplex - 2 nmol
- Included - SR30005, RNAse free siRNA Duplex Resuspension Buffer - 2 ml
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$ 300 |
In Stock |
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| TT300001 |
- SiTran1.0: Transfection reagent designed for RNAi duplex (0.5 ml)
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$220 |
In Stock |
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* These siRNA duplexes were designed to be effective against all transcriptional variants at this gene locus.
** Delivery time is an estimate in business days. Occasional delays may occur due to unforeseen complexities in the preparation of your construct. International customers may expect an additional 1-2 weeks in shipping
Also for NR1I3 (Locus ID 9970)
OriGene Data
| Amount: 2 nmol each, lyophilized | Purity: HPLC purified |
| Quality Control: Tested by ESI-MS | Sequences: Available with shipment |
| Stability: One year from date of shipment when stored at -20ºC | Shipment: Ambient |
| # of transfections: Approximately 330 transfections/2nmol in 24-well plate under optimized conditions (final conc. 10 nM) |
| Note: Single siRNA duplex (10nmol) can be ordered. See details at http://www.origene.com/siRNA/ |
Reference Data
RefSeq: NM_001077469NM_001077470NM_001077471NM_001077472NM_001077473NM_001077474NM_001077475
NM_001077476NM_001077477NM_001077478NM_001077479NM_001077480NM_001077481NM_001077482NM_005122 |
| Synonyms: CAR; CAR1; MB67 |
| Summary: This gene encodes a member of the nuclear receptor superfamily, and is a key regulator of xenobiotic and endobiotic metabolism. The protein binds to DNA as a monomer or a heterodimer with the retinoid X receptor and regulates the transcription of target genes involved in drug metabolism and bilirubin clearance, such as cytochrome P450 family members. Unlike most nuclear receptors, this transcriptional regulator is constitutively active in the absence of ligand but is regulated by both agonists and inverse agonists. Ligand binding results in translocation of this protein to the nucleus, where it activates or represses target gene transcription. These ligands include bilirubin, a variety of foreign compounds, steroid hormones, and prescription drugs. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]. |
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Performance Guranteed:
OriGene guarantees that at least two of the three Dicer-Substrate duplexes in the kit will provide at least 70% or more knockdown of the target mRNA when used at 10 nM concentration by quantitative RT-PCR when the TYE-563 fluorescent transfection control duplex (cat# SR30002) indicates that >90% of the cells have been transfected and the HPRT positive control (cat# SR30003) provides 90% knockdown efficiency.
For non-conforming siRNA, requests for replacement product must be made within ninety (90) days from the date of delivery of the siRNA kit. To arrange for a free replacement with newly designed duplexes, please contact Technical Services at techsupport@origene.com. Please provide your data indicating the transfection efficiency and measurement of gene expression knockdown compared to the scrambled siRNA control (quantitative RT-PCR data required).
siRNA Citations:
CD163 and IgG Codefend against Cytotoxic Hemoglobin via Autocrine and Paracrine Mechanisms, Karthik Subramanian, Ruijuan Du, Nguan Soon Tan, Bow Ho, and Jeak Ling Ding,
J. Immunol., May 2013; 190: 5267 - 5278.
[FCGR2A ]
CD163 and IgG Codefend against Cytotoxic Hemoglobin via Autocrine and Paracrine Mechanisms, Karthik Subramanian, Ruijuan Du, Nguan Soon Tan, Bow Ho, and Jeak Ling Ding,
J. Immunol., May 2013; 190: 5267 - 5278.
[FCGR3A ]
The Syndecan-4/Protein Kinase Ca Pathway Mediates Prostaglandin E2-induced Extracellular Regulated Kinase (ERK) Activation in Endothelial Cells and Angiogenesis in Vivo, Federico Corti, Federica Finetti, Marina Ziche, and Michael Simons,
J. Biol. Chem., May 2013; 288: 12712 - 12721.
[PRKCA ]
Acetylated hsp70 and KAP1-mediated Vps34 SUMOylation is required for autophagosome creation in autophagy, Yonghua Yang, Warren Fiskus, Bao Yong, Peter Atadja, Yoshinori Takahashi, Tej K. Pandita, Hong-Gang Wang, and Kapil N. Bhalla,
PNAS, Apr 2013; 110: 6841 - 6846.
[KAP1 ]
GX15-070 (Obatoclax) Induces Apoptosis and Inhibits Cathepsin D- and L–Mediated Autophagosomal Lysis in Antiestrogen-Resistant Breast Cancer Cells, Jessica L. Schwartz-Roberts, Ayesha N. Shajahan, Katherine L. Cook, Anni Wärri, Mones Abu-Asab, and Robert Clarke,
Mol. Cancer Ther., Apr 2013; 12: 448 - 459.
[BECN1 ]
SCO2 Induces p53-Mediated Apoptosis by Thr845 Phosphorylation of ASK-1 and Dissociation of the ASK-1–Trx Complex, Esha Madan, Rajan Gogna, Periannan Kuppusamy, Madan Bhatt, Abbas Ali Mahdi, and Uttam Pati,
Mol. Cell. Biol., Apr 2013; 33: 1285 - 1302.
[p53]
SCO2 Induces p53-Mediated Apoptosis by Thr845 Phosphorylation of ASK-1 and Dissociation of the ASK-1–Trx Complex, Esha Madan, Rajan Gogna, Periannan Kuppusamy, Madan Bhatt, Abbas Ali Mahdi, and Uttam Pati,
Mol. Cell. Biol., Apr 2013; 33: 1285 - 1302.
[SCO2]
IL-27 inhibits HIV-1 infection in human macrophages by down-regulating host factor SPTBN1 during monocyte to macrophage differentiation, Lue Dai, Kristy B. Lidie, Qian Chen, Joseph W. Adelsberger, Xin Zheng, DaWei Huang, Jun Yang, Richard A. Lempicki, Tauseef Rehman, Robin L. Dewar, Yanmei Wang, Ronald L. Hornung, Kelsey A. Canizales, Stephen J. Lockett, H. Clifford Lane, and Tomozumi Imamichi,
J. Exp. Med., Mar 2013; 210: 517 - 534.
[SPTBN1 ]
Protein Kinases D2 and D3 Are Novel Growth Regulators in HCC1806 Triple-negative Breast Cancer Cells, QIN HAO, RAYMOND MCKENZIE, HUACHEN GAN, and HUA TANG,
Anticancer Res, Feb 2013; 33: 393 - 399.
[PRKCA]
Targeting the Metastasis Suppressor, NDRG1, Using Novel Iron Chelators: Regulation of Stress Fiber-Mediated Tumor Cell Migration via Modulation of the ROCK1/pMLC2 Signaling Pathway, Jing Sun, Daohai Zhang, Ying Zheng, Qian Zhao, Minhua Zheng, Zaklina Kovacevic, and Des R. Richardson,
Mol. Pharmacol., Feb 2013; 83: 454 - 469.
[ROCK1 ]
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