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Home siRNA SR303873
PTGS2 (ID 5743) Trilencer-27 Human siRNA
| Catalog No. |
Description |
Price |
Availability* |
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| SR303873 |
- PTGS2 (Human) - 3 unique 27mer siRNA duplexes - 2 nmol each (Locus ID 5743)
- Included - SR30004, Trilencer-27 Universal Scrambled Negative Control siRNA Duplex - 2 nmol
- Included - SR30005, RNAse free siRNA Duplex Resuspension Buffer - 2 ml
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$ 300 |
In Stock |
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| TT300001 |
- SiTran1.0: Transfection reagent designed for RNAi duplex (0.5 ml)
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$220 |
In Stock |
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* These siRNA duplexes were designed to be effective against all transcriptional variants at this gene locus.
** Delivery time is an estimate in business days. Occasional delays may occur due to unforeseen complexities in the preparation of your construct. International customers may expect an additional 1-2 weeks in shipping
Also for PTGS2 (Locus ID 5743)
OriGene Data
| Amount: 2 nmol each, lyophilized | Purity: HPLC purified |
| Quality Control: Tested by ESI-MS | Sequences: Available with shipment |
| Stability: One year from date of shipment when stored at -20ºC | Shipment: Ambient |
| # of transfections: Approximately 330 transfections/2nmol in 24-well plate under optimized conditions (final conc. 10 nM) |
| Note: Single siRNA duplex (10nmol) can be ordered. See details at http://www.origene.com/siRNA/ |
Reference Data
| RefSeq: NM_000963 |
| Synonyms: COX-2; COX2; GRIPGHS; hCox-2; PGG/HS; PGHS-2; PHS-2 |
| Summary: Prostaglandin-endoperoxide synthase (PTGS), also known as cyclooxygenase, is the key enzyme in prostaglandin biosynthesis, and acts both as a dioxygenase and as a peroxidase. There are two isozymes of PTGS: a constitutive PTGS1 and an inducible PTGS2, which differ in their regulation of expression and tissue distribution. This gene encodes the inducible isozyme. It is regulated by specific stimulatory events, suggesting that it is responsible for the prostanoid biosynthesis involved in inflammation and mitogenesis. [provided by RefSeq, Feb 2009]. |
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Performance Guranteed:
OriGene guarantees that at least two of the three Dicer-Substrate duplexes in the kit will provide at least 70% or more knockdown of the target mRNA when used at 10 nM concentration by quantitative RT-PCR when the TYE-563 fluorescent transfection control duplex (cat# SR30002) indicates that >90% of the cells have been transfected and the HPRT positive control (cat# SR30003) provides 90% knockdown efficiency.
For non-conforming siRNA, requests for replacement product must be made within ninety (90) days from the date of delivery of the siRNA kit. To arrange for a free replacement with newly designed duplexes, please contact Technical Services at techsupport@origene.com. Please provide your data indicating the transfection efficiency and measurement of gene expression knockdown compared to the scrambled siRNA control (quantitative RT-PCR data required).
The use of this siRNA has been cited in the following citations:
Ubiquitin-Proteasomal Degradation of COX-2 in TGF-ß Stimulated Human Endometrial Cells Is Mediated Through Endoplasmic Reticulum Mannosidase I
, Mohan Singh, Parvesh Chaudhry, Sophie Parent, and Eric Asselin,
Endocrinology, Jan 2012; 153: 426 - 437.
[PTGS2
]
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