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Home siRNA SR302124

HLA (ID 3119) Trilencer-27 Human siRNA

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Specifications Citations Related Products Product Documents
Catalog No. Description Price Availability*  
SR302124
  • HLA (Human) - 3 unique 27mer siRNA duplexes - 2 nmol each (Locus ID 3119)
  • Included - SR30004, Trilencer-27 Universal Scrambled Negative Control siRNA Duplex - 2 nmol
  • Included - SR30005, RNAse free siRNA Duplex Resuspension Buffer - 2 ml
390
$290
2 weeks Add to Shopping Cart
TT300001
  • SiTran1.0: Transfection reagent designed for RNAi duplex (0.5 ml)
$220 In Stock Add to Shopping Cart
* These siRNA duplexes were designed to be effective against all transcriptional variants at this gene locus.
** Delivery time is an estimate in business days. Occasional delays may occur due to unforeseen complexities in the preparation of your construct. International customers may expect an additional 1-2 weeks in shipping.
*** Promotion ends Sept 30th.
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Also for HLA (Locus ID 3119)
cDNA Clone qPCR Master Mix Primer Pair shRNA Antibody
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OriGene Data
Amount: 2 nmol each, lyophilizedPurity: HPLC purified
Quality Control: Tested by ESI-MSSequences: Available with shipment
Stability: One year from date of shipment when stored at -20ºCShipment: Ambient
# of transfections: Approximately 330 transfections/2nmol in 24-well plate under optimized conditions (final conc. 10 nM)
Note: Single siRNA duplex (10nmol) can be ordered. See details at http://www.origene.com/siRNA/

Reference Data
RefSeq: BC012106NM_001243961NM_001243962NM_002123
Synonyms: IDDM1
Summary: HLA-DQB1 belongs to the HLA class II beta chain paralogs. This class II molecule is a heterodimer consisting of an alpha (DQA) and a beta chain (DQB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and it contains six exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DQ molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to four different molecules. Typing for these polymorphisms is routinely done for bone marrow transplantation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2011].
Performance Guranteed:
OriGene guarantees that at least two of the three Dicer-Substrate duplexes in the kit will provide at least 70% or more knockdown of the target mRNA when used at 10 nM concentration by quantitative RT-PCR when the TYE-563 fluorescent transfection control duplex (cat# SR30002) indicates that >90% of the cells have been transfected and the HPRT positive control (cat# SR30003) provides 90% knockdown efficiency.

For non-conforming siRNA, requests for replacement product must be made within ninety (90) days from the date of delivery of the siRNA kit. To arrange for a free replacement with newly designed duplexes, please contact Technical Services at techsupport@origene.com. Please provide your data indicating the transfection efficiency and measurement of gene expression knockdown compared to the scrambled siRNA control (quantitative RT-PCR data required).

 

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