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Home siRNA SR301484

EWSR1 (ID 2130) Trilencer-27 Human siRNA

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Specifications Citations Related Products Product Documents
Catalog No. Description Price Availability*  
SR301484
  • EWSR1 (Human) - 3 unique 27mer siRNA duplexes - 2 nmol each (Locus ID 2130)
  • Included - SR30004, Trilencer-27 Universal Scrambled Negative Control siRNA Duplex - 2 nmol
  • Included - SR30005, RNAse free siRNA Duplex Resuspension Buffer - 2 ml
390
$290
In Stock Add to Shopping Cart
TT300001
  • SiTran1.0: Transfection reagent designed for RNAi duplex (0.5 ml)
$220 In Stock Add to Shopping Cart
* These siRNA duplexes were designed to be effective against all transcriptional variants at this gene locus.
** Delivery time is an estimate in business days. Occasional delays may occur due to unforeseen complexities in the preparation of your construct. International customers may expect an additional 1-2 weeks in shipping.
*** Promotion ends Sept 30th.
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Also for EWSR1 (Locus ID 2130)
cDNA Clone qPCR Master Mix Primer Pair shRNA Antibody
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OriGene Data
Amount: 2 nmol each, lyophilizedPurity: HPLC purified
Quality Control: Tested by ESI-MSSequences: Available with shipment
Stability: One year from date of shipment when stored at -20ºCShipment: Ambient
# of transfections: Approximately 330 transfections/2nmol in 24-well plate under optimized conditions (final conc. 10 nM)
Note: Single siRNA duplex (10nmol) can be ordered. See details at http://www.origene.com/siRNA/

Reference Data
RefSeq: AK096787BC000527NM_001163285NM_001163286NM_001163287NM_005243NM_013986
XM_086481XM_086485
Synonyms: EWS;Ewings sarcoma EWS-Fli1 (type 1) oncogene; bK984G1.4 (Ewing sarcoma breakpoint region 1 protein); Ewing sarcoma breakpoint region 1
Summary: This gene encodes a multifunctional protein that is involved in various cellular processes, including gene expression, cell signaling, and RNA processing and transport. The protein includes an N-terminal transcriptional activation domain and a C-terminal RNA-binding domain. Chromosomal translocations between this gene and various genes encoding transcription factors result in the production of chimeric proteins that are involved in tumorigenesis. These chimeric proteins usually consist of the N-terminal transcriptional activation domain of this protein fused to the C-terminal DNA-binding domain of the transcription factor protein. Mutations in this gene, specifically a t(11;22)(q24;q12) translocation, are known to cause Ewing sarcoma as well as neuroectodermal and various other tumors. Alternative splicing of this gene results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 1 and 14. [provided by RefSeq, Jul 2009].
Performance Guranteed:
OriGene guarantees that at least two of the three Dicer-Substrate duplexes in the kit will provide at least 70% or more knockdown of the target mRNA when used at 10 nM concentration by quantitative RT-PCR when the TYE-563 fluorescent transfection control duplex (cat# SR30002) indicates that >90% of the cells have been transfected and the HPRT positive control (cat# SR30003) provides 90% knockdown efficiency.

For non-conforming siRNA, requests for replacement product must be made within ninety (90) days from the date of delivery of the siRNA kit. To arrange for a free replacement with newly designed duplexes, please contact Technical Services at techsupport@origene.com. Please provide your data indicating the transfection efficiency and measurement of gene expression knockdown compared to the scrambled siRNA control (quantitative RT-PCR data required).

 

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