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Home siRNA SR300469

BRCA1 (ID 672) Trilencer-27 Human siRNA

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Specifications Citations Related Products Product Documents
Catalog No. Description Price Availability*  
SR300469
  • BRCA1 (Human) - 3 unique 27mer siRNA duplexes - 2 nmol each (Locus ID 672)
  • Included - SR30004, Trilencer-27 Universal Scrambled Negative Control siRNA Duplex - 2 nmol
  • Included - SR30005, RNAse free siRNA Duplex Resuspension Buffer - 2 ml
300 In Stock Add to Shopping Cart
TT300001
  • SiTran1.0: Transfection reagent designed for RNAi duplex (0.5 ml)
$220 In Stock Add to Shopping Cart
* These siRNA duplexes were designed to be effective against all transcriptional variants at this gene locus.
** Delivery time is an estimate in business days. Occasional delays may occur due to unforeseen complexities in the preparation of your construct. International customers may expect an additional 1-2 weeks in shipping.
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OriGene Data
Amount: 2 nmol each, lyophilizedPurity: HPLC purified
Quality Control: Tested by ESI-MSSequences: Available with shipment
Stability: One year from date of shipment when stored at -20ºCShipment: Ambient
# of transfections: Approximately 330 transfections/2nmol in 24-well plate under optimized conditions (final conc. 10 nM)
Note: Single siRNA duplex (10nmol) can be ordered. See details at http://www.origene.com/siRNA/

Reference Data
RefSeq: NM_007294NM_007295NM_007296NM_007297NM_007298NM_007299NM_007300
NM_007301NM_007302NM_007303NM_007304NM_007305NM_007306NR_027676
Synonyms: IRIS, PSCP, BRCAI, BRCC1, RNF53;BRCAI; BRCC1; IRIS; PSCP; RNF53; BRCA1/BRCA2-containing complex, subunit 1; breast and ovarian cancer susceptibility protein 1; breast cancer 1, early onset
Summary: This gene encodes a nuclear phosphoprotein that plays a role in maintaining genomic stability, and it also acts as a tumor suppressor. The encoded protein combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as the BRCA1-associated genome surveillance complex (BASC). This gene product associates with RNA polymerase II, and through the C-terminal domain, also interacts with histone deacetylase complexes. This protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. Mutations in this gene are responsible for approximately 40% of inherited breast cancers and more than 80% of inherited breast and ovarian cancers. Alternative splicing plays a role in modulating the subcellular localization and physiological function of this gene. Many alternatively spliced transcript variants, some of which are disease-associated mutations, have been described for this gene, but the full-length natures of only some of these variants has been described. A related pseudogene, which is also located on chromosome 17, has been identified. [provided by RefSeq, May 2009].
Performance Guranteed:
OriGene guarantees that at least two of the three Dicer-Substrate duplexes in the kit will provide at least 70% or more knockdown of the target mRNA when used at 10 nM concentration by quantitative RT-PCR when the TYE-563 fluorescent transfection control duplex (cat# SR30002) indicates that >90% of the cells have been transfected and the HPRT positive control (cat# SR30003) provides 90% knockdown efficiency.

For non-conforming siRNA, requests for replacement product must be made within ninety (90) days from the date of delivery of the siRNA kit. To arrange for a free replacement with newly designed duplexes, please contact Technical Services at techsupport@origene.com. Please provide your data indicating the transfection efficiency and measurement of gene expression knockdown compared to the scrambled siRNA control (quantitative RT-PCR data required).

 

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