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Home siRNA SR300330
ATM (ID 472) Trilencer-27 Human siRNA
| Catalog No. |
Description |
Price |
Availability* |
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| SR300330 |
- ATM (Human) - 3 unique 27mer siRNA duplexes - 2 nmol each (Locus ID 472)
- Included - SR30004, Trilencer-27 Universal Scrambled Negative Control siRNA Duplex - 2 nmol
- Included - SR30005, RNAse free siRNA Duplex Resuspension Buffer - 2 ml
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$ 300 |
In Stock |
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| TT300001 |
SiTran1.0: Transfection reagent designed for RNAi duplex (0.5 ml)
Free! With the purchase of 2 siRNA kits (save $220)
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$220 |
In Stock |
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* These siRNA duplexes were designed to be effective against all transcriptional variants at this gene locus.
** Delivery time is an estimate in business days. Occasional delays may occur due to unforeseen complexities in the preparation of your construct. International customers may expect an additional 1-2 weeks in shipping
Also for ATM (Locus ID 472)
OriGene Data
| Amount: 2 nmol each, lyophilized | Purity: HPLC purified |
| Quality Control: Tested by ESI-MS | Sequences: Available with shipment |
| Stability: One year from date of shipment when stored at -20ºC | Shipment: Ambient |
| # of transfections: Approximately 330 transfections/2nmol in 24-well plate under optimized conditions (final conc. 10 nM) |
| Note: Single siRNA duplex (10nmol) can be ordered. See details at http://www.origene.com/siRNA/ |
Reference Data
| RefSeq: BC007023NM_000051NM_138292NM_138293 |
| Synonyms: AT1; ATA; ATC; ATD; ATDC; ATE; TEL1; TELO1 |
| Summary: The protein encoded by this gene belongs to the PI3/PI4-kinase family. This protein is an important cell cycle checkpoint kinase that phosphorylates; thus, it functions as a regulator of a wide variety of downstream proteins, including tumor suppressor proteins p53 and BRCA1, checkpoint kinase CHK2, checkpoint proteins RAD17 and RAD9, and DNA repair protein NBS1. This protein and the closely related kinase ATR are thought to be master controllers of cell cycle checkpoint signaling pathways that are required for cell response to DNA damage and for genome stability. Mutations in this gene are associated with ataxia telangiectasia, an autosomal recessive disorder. [provided by RefSeq, Aug 2010]. |
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Performance Guranteed:
OriGene guarantees that at least two of the three Dicer-Substrate duplexes in the kit will provide at least 70% or more knockdown of the target mRNA when used at 10 nM concentration by quantitative RT-PCR when the TYE-563 fluorescent transfection control duplex (cat# SR30002) indicates that >90% of the cells have been transfected and the HPRT positive control (cat# SR30003) provides 90% knockdown efficiency.
For non-conforming siRNA, requests for replacement product must be made within ninety (90) days from the date of delivery of the siRNA kit. To arrange for a free replacement with newly designed duplexes, please contact Technical Services at techsupport@origene.com. Please provide your data indicating the transfection efficiency and measurement of gene expression knockdown compared to the scrambled siRNA control (quantitative RT-PCR data required).
The use of this siRNA has been cited in the following citations:
Apoptosis-related protein-2 triggers melanoma cell death by a mechanism including both endoplasmic reticulum stress and mitochondrial dysregulation
, Denis Selimovic, Mutmid Ahmad, Abdelouahid El-Khattouti, Matthias Hannig, Youssef Haïkel, and Mohamed Hassan,
Carcinogenesis, Aug 2011; 32: 1268 - 1278.
[ATM]
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