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Home Recombinant Human Proteins All VEGFA Proteins

VEGFA (NM_001025366) Purified Human Protein

Specifications Citations Customer Service Product Documents
Cat. No. Description Datasheet Price Availability*  
TP780001 Recombinant protein of human Vascular endothelial growth factor A (VEGF) produced in Pichia Pastoris., 50 ug (Larger pack size?) 399 In Stock
TA500042 VEGFA (VEGF) mouse monoclonal antibody, clone 4G3 $379 In Stock
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Also for VEGFA (NM_001025366)
cDNA Clone shRNA/siRNA Primer Pair Lysate Antibody

OriGene Data
Species:Human Expression Host:Pichia Pastoris
Expression cDNA Clone or AA Sequence
A DNA sequence from TrueORF clone, RC229662. Encoding the region (Ala27-Arg191) of human VEGFA
Tag:Tag-free Predicted MW:19.2 kDa
Purity:>95% as determined by SDS-PAGE and Coomassie blue staining
Concentration:Resuspend the protein to the desired concentration in proper buffer.
Buffer:Lyophilized from a sterile solution containing 20 mM phosphate buffer, pH7.2
Endotoxin: <0.1 EU per 1 µg of the protein by the LAL
BioActivity: Measured in a cell proliferation assay using HUVEC Cells. The ED50 for this effect is typically 1.1 - 1.6 ng/ml.
Protein Families: Secreted ProteinDruggable Genome
Protein Pathways: Cytokine-cytokine receptor interactionmTOR signaling pathwayVEGF signaling pathwayFocal adhesionPathways in cancerRenal cell carcinomaMore Pathways >>
Protein Data
Protein Image
 

Reference Data
RefSeq: NP_001020537 RefSeq Size: 3665 RefSeq ORF: 1239
LocusID: 7422 Cytogenetic: 6p12  
Synonyms : MVCD1; VEGF; VPF
Summary: This gene is a member of the PDGF/VEGF growth factor family and encodes a protein that is often found as a disulfide linked homodimer. This protein is a glycosylated mitogen that specifically acts on endothelial cells and has various effects, including mediating increased vascular permeability, inducing angiogenesis, vasculogenesis and endothelial cell growth, promoting cell migration, and inhibiting apoptosis. Elevated levels of this protein is linked to POEMS syndrome, also known as Crow-Fukase syndrome. Mutations in this gene have been associated with proliferative and nonproliferative diabetic retinopathy. Alternatively spliced transcript variants, encoding either freely secreted or cell-associated isoforms, have been characterized. There is also evidence for the use of non-AUG (CUG) translation initiation sites upstream of, and in-frame with the first AUG, leading to additional isoforms. [provided by RefSeq, Jul 2008].
*: Inventory for certain proteins may be limited due to low expression level. Delivery time may vary from web posted schedule. Contact techsupport@origene.com for specific inventory information
**: DDK-tag is the same as FLAG tag. Flag® is a registered trademark of Sigma-Aldrich

 

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