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Home Recombinant Human Proteins All EDN3 Proteins

EDN3 (NM_000114) Purified Human Protein

Specifications Citations Customer Service Product Documents
Cat. No. Description Datasheet Price Availability*  
TP760408 Purified recombinant protein of Human endothelin 3 (EDN3), transcript variant 1, full length, with N-terminal HIS tag, expressed in E.Coli, 50ug, 50 µg (Larger pack size?) 199 In Stock
TA308462 Rabbit polyclonal antibody to Endothelin 3 (endothelin 3) $325 3-7 Days
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OriGene Data
Species:Human Expression Host:E. coli
Expression cDNA Clone or AA Sequence
A DNA sequence from TrueORF clone, RC220053, encoding human full-length EDN3
Tag:N-terminal HIS Predicted MW:22.8 kDa
Purity:> 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration:>50 ug/mL as determined by microplate BCA method
Buffer:25mM Tris, pH8.0, 150 mM NaCl, 10% glycerol, 1 % Sarkosyl. Store at -80C. Avoid repeated freeze-thaw cycles. Stable for at least 3 months from receipt of products under proper storage and handling conditions.
Endotoxin: NULL
Preparation: NULL
Protein Families: Secreted ProteinDruggable Genome
Protein Pathways:
Protein Data
Protein Image
 

Reference Data
RefSeq: NP_000105 RefSeq Size: 2438 RefSeq ORF: 717
LocusID: 1908 Cytogenetic: 20q13.2-q13.3  
Synonyms : ET-3; ET3; HSCR4; PPET3; WS4B
Summary: The protein encoded by this gene is a member of the endothelin family. Endothelins are endothelium-derived vasoactive peptides involved in a variety of biological functions. The active form of this protein is a 21 amino acid peptide processed from the precursor protein. The active peptide is a ligand for endothelin receptor type B (EDNRB). The interaction of this endothelin with EDNRB is essential for development of neural crest-derived cell lineages, such as melanocytes and enteric neurons. Mutations in this gene and EDNRB have been associated with Hirschsprung disease (HSCR) and Waardenburg syndrome (WS), which are congenital disorders involving neural crest-derived cells. Four alternatively spliced transcript variants encoding three distinct isoforms have been observed. [provided by RefSeq, Jul 2008].
*: Inventory for certain proteins may be limited due to low expression level. Delivery time may vary from web posted schedule. Contact techsupport@origene.com for specific inventory information
**: DDK-tag is the same as FLAG tag. Flag® is a registered trademark of Sigma-Aldrich

 

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