BMP2 (NM_001200) Human Recombinant Protein

CAT#: TP750012

Recombinant protein of human Bone Morphogenetic Protein-2 (BMP2) produced in E. coli.


  View other "BMP2" proteins (4)

USD 515.00

In Stock*

Size
    • 20 ug

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Frequently bought together (1)
BMP2 Rabbit polyclonal Antibody
    • 100 ul

USD 313.00

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Specifications

Product Data
Species Human
Expression Host E. coli
Expression cDNA Clone or AA Sequence
A DNA sequence encoding the region (Gln283-Arg396) of human BMP2
Tag Tag Free
Predicted MW 13 kDa
Concentration Resuspend the protein to the desired concentration in proper buffer.
Purity >95% as determined by SDS-PAGE and Coomassie blue staining
Buffer Lyophilized from a sterile solution containing 10 mM sodium citrate, pH 3.5
Bioactivity Measured?by?its?ability?to?induce?alkaline?phosphatase?production in?ATDC5?cells. ED50 for this effect is typically 36 - 55 ng/ml.
Co-immunoprecipitation (PMID: 28009989)
Endotoxin < 0.1 EU per 1 µg of the protein by the LAL
Note For testing in cell culture applications, please filter before use. Note that you may experience some loss of protein during the filtration process.
Storage Store at -80°C.
Stability Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
Reference Data
RefSeq NP_001191
Locus ID 650
UniProt ID P12643, C8C060
Cytogenetics 20p12.3
Refseq Size 1547
Refseq ORF 1188
Synonyms BDA2; BMP2A; SSFSC; SSFSC1
Summary This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer, which plays a role in bone and cartilage development. Duplication of a regulatory region downstream of this gene causes a form of brachydactyly characterized by a malformed index finger and second toe in human patients. [provided by RefSeq, Jul 2016]
Protein Families Adult stem cells, Cancer stem cells, Druggable Genome, Embryonic stem cells, ES Cell Differentiation/IPS, Induced pluripotent stem cells, Secreted Protein, Stem cell relevant signaling - TGFb/BMP signaling pathway, Transmembrane
Protein Pathways Acute myeloid leukemia, Basal cell carcinoma, Cytokine-cytokine receptor interaction, Endocytosis, Hedgehog signaling pathway, Hematopoietic cell lineage, Melanogenesis, Pathways in cancer, TGF-beta signaling pathway

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