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EBI3 (NM_005755) Purified Human Protein

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Cat. No. Description Datasheet Price Availability*  
TP723851 Purified recombinant protein of Human Epstein-Barr virus induced 3 (EBI3), 10 ug (Larger pack size?) 299
5 days
TA150088 Clone OTI2B5, Anti-His mouse monoclonal antibody $248 In Stock
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OriGene Data
Species:Human Expression Host:CHO cells
Expression cDNA Clone or AA Sequence
Human IL-27, consisting two subunits, EBI3, the region of Arg21-Lys229, from gene Accession# NM_005755 , and p28, the region of Phe29-Pro243, from gene Accession# NM_145659, linked via a GS bridge
Tag:C-terminal His Predicted MW:50 kDa
Purity:>95%, as determined by Coomassie stained SDS-PAGE.
Concentration:Protein formulated and vialed at >50 ug/mL in specified buffer
Buffer:20 mM NaHPO4, pH6, 0.60 M NaCl.
Endotoxin: Less than 0.01 ng per µg protein as determined by the LAL method.
BioActivity: The ED50 is 60 - 90 ng/ml, corresponding to a specific activity of 1.1 - 1.7 x 10^4 units/mg, determined by mouse splenocytes IL-2 inhibition induced by hIL-27 in mouse splenocytes activated with anti-CD3 and anti-CD28 antibodies.
Protein Families: Secreted ProteinDruggable Genome
Protein Pathways:

Reference Data
RefSeq: NP_005746 RefSeq Size: 1149 RefSeq ORF: 687
LocusID: 10148 Cytogenetic: 19p13.3  
Synonyms : IL-27B; IL27B
Summary: This gene was identified by its induced expression in B lymphocytes in response Epstein-Barr virus infection. It encodes a secreted glycoprotein belonging to the hematopoietin receptor family, and heterodimerizes with a 28 kDa protein to form interleukin 27 (IL-27). IL-27 regulates T cell and inflammatory responses, in part by activating the Jak/STAT pathway of CD4+ T cells. [provided by RefSeq, Sep 2008]
*: Inventory for certain proteins may be limited due to low expression level. Delivery time may vary from web posted schedule. Contact techsupport@origene.com for specific inventory information
**: DDK-tag is the same as FLAG tag. Flag® is a registered trademark of Sigma-Aldrich


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