Promotion ends on May 1st.
Also for ZAP70 (NM_001079)
|Expression cDNA Clone or AA Sequence
Recombinant protein was produced with TrueORF clone, RC208838
. Click on the TrueORF clone link to view cDNA and protein sequences.
||Predicted MW:||69.7 kDa|
|Purity:||> 80% as determined by SDS-PAGE and Coomassie blue staining|
|Concentration:||>50 ug/mL as determined by microplate BCA method|
|Buffer:||25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.|
||Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
||Protein KinaseDruggable Genome
||Natural killer cell mediated cytotoxicityT cell receptor signaling pathwayPrimary immunodeficiency
||RefSeq Size: 2450
||RefSeq ORF: 1860|
|Synonyms : SRK; STCD; STD; TZK; ZAP-70|
|Summary: This gene encodes an enzyme belonging to the protein tyrosine kinase family, and it plays a role in T-cell development and lymphocyte activation. This enzyme, which is phosphorylated on tyrosine residues upon T-cell antigen receptor (TCR) stimulation, functions in the initial step of TCR-mediated signal transduction in combination with the Src family kinases, Lck and Fyn. This enzyme is also essential for thymocyte development. Mutations in this gene cause selective T-cell defect, a severe combined immunodeficiency disease characterized by a selective absence of CD8-positive T-cells. Two transcript variants that encode different isoforms have been found for this gene. [provided by RefSeq, Jul |
*: Inventory for certain proteins may be limited due to low expression level. Delivery time may vary from web posted schedule. Contact firstname.lastname@example.org
for specific inventory information
**: DDK-tag is the same as FLAG tag. Flag® is a registered trademark of Sigma-Aldrich