Promotion ends on May 1st.
Also for E2F1 (NM_005225)
|Expression cDNA Clone or AA Sequence
Recombinant protein was produced with TrueORF clone, RC208247
. Click on the TrueORF clone link to view cDNA and protein sequences.
||Predicted MW:||46.7 kDa|
|Purity:||> 80% as determined by SDS-PAGE and Coomassie blue staining|
|Concentration:||>50 ug/mL as determined by microplate BCA method|
|Buffer:||25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.|
||Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
||Transcription FactorsDruggable Genome
||Cell cyclePathways in cancerPancreatic cancerGliomaProstate cancerMelanomaMore Pathways >>
||RefSeq Size: 2486
||RefSeq ORF: 1314|
|Synonyms : E2F-1; RBAP1; RBBP3; RBP3|
|Summary: The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein and another 2 members, E2F2 and E2F3, have an additional cyclin binding domain. This protein binds preferentially to retinoblastoma protein pRB in a cell-cycle dependent manner. It can mediate both cell proliferation and p53-dependent/independent apoptosis. [provided by RefSeq, Jul 2008]. |
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for specific inventory information
**: DDK-tag is the same as FLAG tag. Flag® is a registered trademark of Sigma-Aldrich