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Home Recombinant Human Proteins All AKR1C4 Proteins

AKR1C4 (NM_001818) Purified Human Protein

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Cat. No. Description Datasheet Price Availability*  
TP304731 Recombinant protein of human aldo-keto reductase family 1, member C4 (chlordecone reductase; 3-alpha hydroxysteroid dehydrogenase, type I; dihydrodiol dehydrogenase 4) (AKR1C4), 20 ug (Larger pack size?) $680 In Stock
TA500914 anti-HDHD2 mouse monoclonal antibody, clone OTI2C12 (formerly 2C12) $325 In Stock
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OriGene Data
Species:Human Expression Host:HEK293 cells
Expression cDNA Clone or AA Sequence
Recombinant protein was produced with TrueORF clone, RC204731. Click on the TrueORF clone link to view cDNA and protein sequences.
Tag:C-terminal MYC/DDK Predicted MW:36.9 kDa
Purity:> 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration:>50 ug/mL as determined by microplate BCA method
Buffer:25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Preparation: Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
Protein Families: Druggable Genome
Protein Pathways: Primary bile acid biosynthesisC21-Steroid hormone metabolismAndrogen and estrogen metabolismMetabolism of xenobiotics by cytochrome P450Metabolic pathways
Protein Data
Protein Image
 

Reference Data
RefSeq: NP_001809 RefSeq Size: 1194 RefSeq ORF: 972
LocusID: 1109 Cytogenetic: 10p15.1  
Synonyms : 3-alpha-HSD; C11; CDR; CHDR; DD-4; DD4; HAKRA
Summary: This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols by utilizing NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme catalyzes the bioreduction of chlordecone, a toxic organochlorine pesticide, to chlordecone alcohol in liver. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14. [provided by RefSeq, Jul 2008].
*: Inventory for certain proteins may be limited due to low expression level. Delivery time may vary from web posted schedule. Contact techsupport@origene.com for specific inventory information
**: DDK-tag is the same as FLAG tag. Flag® is a registered trademark of Sigma-Aldrich

 

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