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Home Recombinant Human Proteins All HDAC1 Proteins

HDAC1 (NM_004964) Purified Human Protein

Specifications Citations Customer Service Product Documents
Cat. No. Description Datasheet Price Availability*  
TP301745 Recombinant protein of human histone deacetylase 1 (HDAC1), 20 ug (Larger pack size?) 680 In Stock
TA502193 HDAC1 mouse monoclonal antibody, clone 5F9 $379 In Stock
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Also for HDAC1 (NM_004964)
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OriGene Data
Species:Human Expression Host:HEK293 cells
Expression cDNA Clone or AA Sequence
Recombinant protein was produced with TrueORF clone, RC201745. Click on the TrueORF clone link to view cDNA and protein sequences.
Tag:C-terminal MYC/DDK Predicted MW:54.9 kDa
Purity:> 80% as determined by SDS-PAGE and Coomassie blue staining
Mass Spec Validation: This protein has been positively validated by MS/MS by Dr. Robert Moritz at The Institute of Systems Biology.
Concentration:>50 ug/mL as determined by microplate BCA method
Buffer:25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Preparation: Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
Protein Families: Stem cell relevant signaling - DSL/Notch pathwayStem cell - PluripotencyAdult stem cellsTranscription FactorsDruggable Genome
Protein Pathways: Cell cycleNotch signaling pathwayHuntington's diseasePathways in cancerChronic myeloid leukemia
Protein Data
Protein Image
 

Reference Data
RefSeq: NP_004955 RefSeq Size: 2091 RefSeq ORF: 1449
LocusID: 3065 Cytogenetic: 1p34  
Synonyms : GON-10; HD1; RPD3; RPD3L1
Summary: Histone acetylation and deacetylation, catalyzed by multisubunit complexes, play a key role in the regulation of eukaryotic gene expression. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family and is a component of the histone deacetylase complex. It also interacts with retinoblastoma tumor-suppressor protein and this complex is a key element in the control of cell proliferation and differentiation. Together with metastasis-associated protein-2, it deacetylates p53 and modulates its effect on cell growth and apoptosis. [provided by RefSeq, Jul 2008].
*: Inventory for certain proteins may be limited due to low expression level. Delivery time may vary from web posted schedule. Contact techsupport@origene.com for specific inventory information
**: DDK-tag is the same as FLAG tag. Flag® is a registered trademark of Sigma-Aldrich

 

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