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Home Recombinant Human Proteins All TGFB1 Proteins

TGFB1 (NM_000660) Purified Human Protein

Specifications Citations (1) Customer Service Product Documents
Cat. No. Description Datasheet Price Availability*  
TP300973 Recombinant protein of human transforming growth factor, beta 1 (TGFB1), 20 ug (Larger pack size?) 680
$398
In Stock
TA506584 TGFB1 mouse monoclonal antibody, clone OTI2B5 (formerly 2B5) $325 In Stock
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OriGene Data
Species:Human Expression Host:HEK293 cells
Expression cDNA Clone or AA Sequence
Recombinant protein was produced with TrueORF clone, RC200973. Click on the TrueORF clone link to view cDNA and protein sequences.
Tag:C-terminal MYC/DDK Predicted MW:28.4 kDa
Purity:> 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration:>50 ug/mL as determined by microplate BCA method
Buffer:25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Preparation: Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
Protein Families: Secreted ProteinES Cell Differentiation/IPSTranscription FactorsDruggable Genome
Protein Pathways: MAPK signaling pathwayCytokine-cytokine receptor interactionCell cycleTGF-beta signaling pathwayPathways in cancerColorectal cancerMore Pathways >>
Protein Data
Protein Image
 

Reference Data
RefSeq: NP_000651 RefSeq Size: 2346 RefSeq ORF: 1170
LocusID: 7040 Cytogenetic: 19q13.2  
Synonyms : CED; DPD1; LAP; TGFB; TGFbeta
Summary: This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate a latency-associated peptide (LAP) and a mature peptide, and is found in either a latent form composed of a mature peptide homodimer, a LAP homodimer, and a latent TGF-beta binding protein, or in an active form consisting solely of the mature peptide homodimer. The mature peptide may also form heterodimers with other TGFB family members. This encoded protein regulates cell proliferation, differentiation and growth, and can modulate expression and activation of other growth factors including interferon gamma and tumor necrosis factor alpha. This gene is frequently upregulated in tumor cells, and mutations in this gene result in Camurati-Engelmann disease. [provided by RefSeq, Aug 2016].
*: Inventory for certain proteins may be limited due to low expression level. Delivery time may vary from web posted schedule. Contact techsupport@origene.com for specific inventory information
**: DDK-tag is the same as FLAG tag. Flag® is a registered trademark of Sigma-Aldrich

 

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