p53 (1-342, C-terminal deletion) Tumor Suppressor Protein and Transcription Factor, 5,000 units

Cat. No.   Description TP200118 P2003-01 p53 (1-342, C-terminal deletion) Tumor Suppressor Protein and Transcription Factor, 5,000 units The associated gene in an expression vector NM_000546 is also available.

Description:

Human p53 protein is composed of 393 amino acid residues with several distinct regions. In addition to that the N-terminal activation domain allows p53 protein to recruit the basal transcription machinery and activate the expression of target genes, the core domain binds to target DNA in a sequence-specific manner and the majority of mutations found in human tumors occur in the region of the gene encoding this domain, and modification of the C-terminal basic domain regulates p53 function (1-4), the tetramerization domain of p53 plays an important role in cell cycle. Disruption or loss of oligomerization function is associated with loss of cell cycle arrest (5, 6). This mutant protein (with the deletion of C-terminus 51 residues including the entire basic domain and portion of tetramerization domain) can be used as a unique tool to study specific function of p53 related to the C-terminus.