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Home cDNA Clone TrueORF All EGFR ORF Clones

EGFR (NM_201284) Human cDNA ORF Clone

Specifications Citations Clones of Other Species Product Documents
Cat. No. Description Price Availability  
RC600004 EGFR (DDK-His-tagged)-Extra Cellular Domain Clone of Homo sapiens epidermal growth factor receptor, transcript variant 4, Signal peptide (1-24) plus EC domain (25-645), 10µg
$680
In Stock
TA50011-100 4C5, Anti-DDK monoclonal antibody, 100µl $248 In Stock
Clone Modification
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TrueORF Data for RC600004
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Vector: pCMV6-XL5-DDK-His   Change vector? Tag: C-terminal DDK-His
Sequence Data: ORF Nucleotide Sequence
Protein Sequence
ORF Size: 1935 bp
Predicted Protein MW: 71.6 kDa
Restriction Sites: SgfI-MluI     Cloning Scheme for this gene     Plasmid Map
OTI Annotation: This clone was engineered to express the extra cellular domain of the protein with an expression tag
OTI Disclaimer: The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
Product Components: The ORF clone is ion-exchange column purified, transfection-ready dried plasmid DNA, and shipped with 2 vector sequencing primers.
Protein Families: Stem cell relevant signaling - JAK/STAT signaling pathwayProtein KinaseSecreted ProteinES Cell Differentiation/IPSTransmembraneAdult stem cellsCancer stem cellsDruggable Genome
Protein Pathways: MAPK signaling pathwayErbB signaling pathwayCalcium signaling pathwayCytokine-cytokine receptor interactionEndocytosisDorso-ventral axis formationMore Pathways >>

Reference Data
RefSeq: NM_201284.1, NP_958441
RefSeq Size: 2865 RefSeq ORF: 2118
Synonyms : ERBB; ERBB1; HER1; mENA; PIG61
LocusID: 1956 Cytogenetic: 7p12
Summary: The protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein kinase superfamily. This protein is a receptor for members of the epidermal growth factor family. EGFR is a cell surface protein that binds to epidermal growth factor. Binding of the protein to a ligand induces receptor dimerization and tyrosine autophosphorylation and leads to cell proliferation. Mutations in this gene are associated with lung cancer. Multiple alternatively spliced transcript variants that encode different protein isoforms have been found for this gene. [provided by RefSeq, Jul 2010].

 

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