OriGene - PAK6 (NM_020168) Human ORF cDNA Clone

Western Blot Validated

The same insert cloned in Lenti and other vectors is also available.

Cat. No.	Description	Vector	Price	Availability
RC207438L1	Lenti ORF clone of Human p21 protein (Cdc42/Rac)-activated kinase 6 (PAK6), transcript variant 1 , Myc-DDK-tagged	pLenti-C-Myc-DDK pLenti-C-mGFP pCMV6-AC-GFP	$910	2 Weeks
TR30022	Lenti-vpak packaging kit - packaging plasmids and transfection reagent (10 rxns)		$360	In Stock

TrueORF Data for RC207438

Vector:	pCMV6-Entry Change vector?	Tag: C-terminal Myc-DDK	Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Sequence Data:	ORF Nucleotide Sequence CHROMATOGRAMS Protein Sequence	ORF Size: 2046 bp Predicted Protein MW: 74.7 kDa
Restriction Sites:	SgfI-MluI Cloning Scheme for this gene Plasmid Map
OTI Annotation:	This clone was engineered to express the complete ORF with an expression tag.
OTI Disclaimer:	The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
Product Components:	The ORF clone is ion-exchange column purified, transfection-ready dried plasmid DNA, and shipped with 2 vector sequencing primers.
Protein Families:	Protein Kinase Druggable Genome
Protein Pathways:	ErbB signaling pathway Axon guidance Focal adhesion T cell receptor signaling pathway Regulation of actin cytoskeleton Renal cell carcinoma

* The lysates used for this WB picture contain the overexpressed empty vector or the Myc-DDK tagged ORF clone.

Reference Data

RefSeq: NM_020168.3, NP_064553	RefSeq Size: 3889	RefSeq ORF: 2046
Synonyms : PAK5
LocusID: 56924	Cytogenetic: 15q14	Domains: PBD, pkinase, TyrKc, S_TKc
Summary: This gene encodes a member of the p21-activated kinase (PAK) family. The proteins of this family are Rac/Cdc42-associated Ste20-like Ser/Thr protein kinases, characterized by a highly conserved amino-terminal Cdc42/Rac interactive binding (CRIB) domain and a carboxyl-terminal kinase domain. PAK kinases are implicated in the regulation of a number of cellular processes, including cytoskeleton rearrangement, apoptosis and the MAP kinase signaling pathway. The protein encoded by this gene was found to interact with androgen receptor (AR), which is a steroid hormone-dependent transcription factor that is important for male sexual differentiation and development. This gene was found to be highly expressed in testis and prostate tissues and the encoded protein was shown to cotranslocate into the nucleus with AR in response to androgen. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008].

ORF Clones Citations:

Solute Carrier 11A1 Is Expressed by Innate Lymphocytes and Augments Their Activation, Jodi F. Hedges, Emily Kimmel, Deann T. Snyder, Maria Jerome, and Mark A. Jutila, J. Immunol., Apr 2013; 190: 4263 - 4273. [SLC11A1]

A common polymorphism in the LDL receptor gene has multiple effects on LDL receptor function, Feng Gao, Hansel E. Ihn, Marisa W. Medina, and Ronald M. Krauss, Hum. Mol. Genet., Apr 2013; 22: 1424 - 1431. [LDLR]

RNA elements directing in vivo assembly of the 7SK/MePCE/Larp7 transcriptional regulatory snRNP, Lisa Muniz, Sylvain Egloff, and Tamás Kiss, Nucleic Acids Res., Apr 2013; 41: 4686 - 4698. [MEPCE ]

Structural basis for angiopoietin-1–mediated signaling initiation, Xuehong Yu, Tom C. M. Seegar, Annamarie C. Dalton, Dorothea Tzvetkova-Robev, Yehuda Goldgur, Kanagalaghatta R. Rajashankar, Dimitar B. Nikolov, and William A. Barton, PNAS, Apr 2013; 110: 7205 - 7210. [ANGPT1]

Inverted Formin 2 Regulates Actin Dynamics by Antagonizing Rho/Diaphanous-related Formin Signaling, Hua Sun, Johannes Schlondorff, Henry N. Higgs, and Martin R. Pollak, J. Am. Soc. Nephrol., Apr 2013; 10.1681/ASN.2012080834. [INF2]

MASL1 induces erythroid differentiation in human erythropoietin-dependent CD34+ cells through the Raf/MEK/ERK pathway, Chutima Kumkhaek, Wulin Aerbajinai, Wenli Liu, Jianqiong Zhu, Naoya Uchida, Roger Kurlander, Matthew M. Hsieh, John F. Tisdale, and Griffin P. Rodgers, Blood, Apr 2013; 121: 3216 - 3227. [MFHAS1 ]

Proximal tubule-dominant transfer of AT1a receptors induces blood pressure responses to intracellular angiotensin II in AT1a receptor-deficient mice, Xiao C. Li and Jia L. Zhuo, Am J Physiol Regulatory Integrative Comp Physiol, Apr 2013; 304: R588 - R598. [AGTR1A ]

DCNL1 Functions as a Substrate Sensor and Activator of Cullin 2-RING Ligase, Pardeep Heir, Roxana I. Sufan, Samantha N. Greer, Betty P. Poon, Jeffrey E. Lee, and Michael Ohh, Mol. Cell. Biol., Apr 2013; 33: 1621 - 1631. [DCNL1]

More TrueClone Citations >>

PAK6 Mouse Clones

SKU	Description	Amount	Price	Shipping
MC220453	Mus musculus p21 protein (Cdc42/Rac)-activated kinase 6 (Pak6), transcript variant 1 as transfection-ready DNA	10 ug	$820	6 weeks
MC220454	Mus musculus p21 protein (Cdc42/Rac)-activated kinase 6 (Pak6), transcript variant 2 as transfection-ready DNA	10 ug	$820	6 weeks
MR216829	Myc-DDK-tagged ORF clone of Mus musculus p21 protein (Cdc42/Rac)-activated kinase 6 (Pak6), transcript variant 2 as transfection-ready DNA	10 ug	$820	Next day
MR218274	Myc-DDK-tagged ORF clone of Mus musculus p21 protein (Cdc42/Rac)-activated kinase 6 (Pak6), transcript variant 1 as transfection-ready DNA	10 ug	$820	6 weeks
MG216829	GFP-tagged ORF clone of Mus musculus p21 protein (Cdc42/Rac)-activated kinase 6 (Pak6) transcript variant 2 as transfection-ready DNA	10 ug	$900	3 weeks
MG218274	GFP-tagged ORF clone of Mus musculus p21 protein (Cdc42/Rac)-activated kinase 6 (Pak6) transcript variant 1 as transfection-ready DNA	10 ug	$900	3 weeks

PAK6 Rat Clones

SKU	Description	Amount	Price	Shipping
RN202028	NativeORF clone of Rattus norvegicus p21 (CDKN1A)-activated kinase 6 (Pak6) as transfection-ready DNA	10 ug	$818	6 weeks
RR202028	Myc-DDK-tagged ORF clone of Rattus norvegicus p21 (CDKN1A)-activated kinase 6 (Pak6) as transfection-ready DNA	10 ug	$818	6 weeks

Don't see the species of your interest?
Use Blue Heron gene synthesis and make clone in any of OriGene's expression vectors.

All Products by:	Title \| Price \| Category \| Popularity \| Best Sellers	Topselling Products by:	Title \| Price \| Category \| Popularity \| Favorites
Popular Categories:	Popularity \| Our Choices \| All-Round Favorites \| Title	Topselling Categories:	Popularity \| Our Choices \| All-Round Favorites \| Title

PAK6 (NM_020168) Human cDNA ORF Clone

Western Blot Validated

ORF Clones Citations:

PAK6 Mouse Clones

PAK6 Rat Clones

Product Manuals

MSDS

FAQs