OriGene - MAP2K4 (NM_003010) Human ORF cDNA Clone

MAP2K4 (NM_003010) Human cDNA ORF Clone

TrueORF Data for RC206051

Vector:	pCMV6-Entry Change vector?	Tag: C-terminal Myc-DDK	Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Sequence Data:	ORF Nucleotide Sequence CHROMATOGRAMS Protein Sequence	ORF Size: 1200 bp Predicted Protein MW: 44.1 kDa
Restriction Sites:	SgfI-MluI Cloning Scheme for this gene Plasmid Map
OTI Annotation:	This clone was engineered to express the complete ORF with an expression tag.
OTI Disclaimer:	The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
Product Components:	The ORF clone is ion-exchange column purified, transfection-ready dried plasmid DNA, and shipped with 2 vector sequencing primers.
Protein Families:	Protein Kinase Druggable Genome
Protein Pathways:	MAPK signaling pathway ErbB signaling pathway Toll-like receptor signaling pathway Fc epsilon RI signaling pathway GnRH signaling pathway Epithelial cell signaling in Helicobacter pylori infection

* The lysates used for this WB picture contain the overexpressed empty vector or the Myc-DDK tagged ORF clone.

Reference Data

RefSeq: NM_003010.2, NP_003001	RefSeq Size: 3752	RefSeq ORF: 1200
Synonyms : JNKK; JNKK1; MAPKK4; MEK4; MKK4; PRKMK4; SAPKK-1; SAPKK1; SEK1; SERK1
LocusID: 6416	Cytogenetic: 17p12	Domains: pkinase, TyrKc, S_TKc
Summary: This gene encodes a dual specificity protein kinase that belongs to the Ser/Thr protein kinase family. This kinase is a direct activator of MAP kinases in response to various environmental stresses or mitogenic stimuli. It has been shown to activate MAPK8/JNK1, MAPK9/JNK2, and MAPK14/p38, but not MAPK1/ERK2 or MAPK3/ERK3. This kinase is phosphorylated, and thus activated by MAP3K1/MEKK. The knockout studies in mice suggested the roles of this kinase in mediating survival signal in T cell development, as well as in the organogenesis of liver. [provided by RefSeq, Jul

SKU	Description	Amount	Price	Shipping
MC209718	Mus musculus mitogen-activated protein kinase kinase 4 (Map2k4) as transfection-ready DNA	10 ug	$380	Next day
MC217773	Mus musculus mitogen activated protein kinase kinase 4 (cDNA clone MGC:36532 IMAGE:3962163) as transfection-ready DNA	10 ug	$650	2 weeks
MR226212	Myc-DDK-tagged ORF clone of Mus musculus mitogen-activated protein kinase kinase 4 (Map2k4) as transfection-ready DNA	10 ug	$380	5 weeks
MR203798	Myc-DDK-tagged ORF clone of Mus musculus mitogen activated protein kinase kinase 4 (cDNA clone MGC:36532 IMAGE:3962163) as transfection-ready DNA	10 ug	$650	Next day
MG226212	GFP-tagged ORF clone of Mus musculus mitogen-activated protein kinase kinase 4 (Map2k4) as transfection-ready DNA	10 ug	$420	3 weeks
MG203798	GFP-tagged ORF clone of Mus musculus mitogen activated protein kinase kinase 4 (cDNA clone MGC:36532 IMAGE:3962163) in a GFP expression vector	10 ug	$720	3 weeks

SKU	Description	Amount	Price	Shipping
RN204032	NativeORF clone of Rattus norvegicus mitogen activated protein kinase kinase 4 (Map2k4) as transfection-ready DNA	10 ug	$380	5 weeks
RR204032	Myc-DDK-tagged ORF clone of Rattus norvegicus mitogen activated protein kinase kinase 4 (Map2k4) as transfection-ready DNA	10 ug	$380	5 weeks

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MAP2K4 (NM_003010) Human cDNA ORF Clone