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Home cDNA Clone TrueORF All EP300 ORF Clones

EP300 (NM_001429) Human cDNA ORF Clone

Western Blot Validated

Specifications Citations (1) Clones of Other Species Product Documents
Cat. No. Description Price Availability  
RC223265 EP300 (Myc-DDK-tagged)-Human E1A binding protein p300 (EP300), 10µg
$1880
In Stock
TA50011-100 4C5, Anti-DDK monoclonal antibody, 100µl $248 In Stock
Clone Modification
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The same insert cloned in Lenti and other vectors is also available.

Cat. No. Description Vector Price Availability  
RC223265L1 Lenti ORF clone of Human E1A binding protein p300 (EP300), Myc-DDK-tagged
$2250 4 Weeks
TR30022 Lenti-vpak packaging kit - packaging plasmids and transfection reagent (10 rxns) Lenti-vpak-app-guide $390 In Stock
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Also for EP300 (NM_001429)
cDNA Clone shRNA/siRNA CRISPR KO Kit Protein Antibody
TrueORF Data for RC223265
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Vector: pCMV6-Entry   Change vector? Tag: C-terminal Myc-DDK
Western validation with an anti-DDK antibody *
L: Control HEK293 lysate
R: Over-expression lysate
Lysate_Image
Sequence Data: ORF Nucleotide Sequence
Protein Sequence
ORF Size: 7245 bp
Predicted Protein MW: 264 kDa
Restriction Sites: SgfI-MluI     Cloning Scheme for this gene     Plasmid Map Plasmid Map
OTI Annotation: This clone was engineered to express the complete ORF with an expression tag.
OTI Disclaimer: Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery.
Product Components: The ORF clone is ion-exchange column purified, transfection-ready dried plasmid DNA, and shipped with 2 vector sequencing primers.
Protein Families: Transcription FactorsDruggable Genome
Protein Pathways: Cell cycleWnt signaling pathwayNotch signaling pathwayTGF-beta signaling pathwayAdherens junctionJak-STAT signaling pathwayMore Pathways >>

Reference Data
RefSeq: NM_001429.2, NP_001420
RefSeq Size: 8765 RefSeq ORF: 7245
Synonyms : KAT3B; p300; RSTS2
LocusID: 2033 Cytogenetic: 22q13.2 Domains: ZnF_TAZ, ZnF_ZZ, bromodomain, KIX
Summary: This gene encodes the adenovirus E1A-associated cellular p300 transcriptional co-activator protein. It functions as histone acetyltransferase that regulates transcription via chromatin remodeling and is important in the processes of cell proliferation and differentiation. It mediates cAMP-gene regulation by binding specifically to phosphorylated CREB protein. This gene has also been identified as a co-activator of HIF1A (hypoxia-inducible factor 1 alpha), and thus plays a role in the stimulation of hypoxia-induced genes such as VEGF. Defects in this gene are a cause of Rubinstein-Taybi syndrome and may also play a role in epithelial cancer. [provided by RefSeq, Jul 2008].

 

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