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Home cDNA Clone TrueORF All MET ORF Clones

MET (NM_001127500) Human cDNA ORF Clone

Specifications Citations Clones of Other Species Product Documents
Cat. No. Description Price Availability  
RC600031 MET (DDK-His-tagged)-Extra Cellular Domain Clone of Homo sapiens met proto-oncogene (hepatocyte growth factor receptor), transcript variant 1, Signal peptide (1-24) plus EC domain (25-950), 10µg   
$1030
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TA50011-100 4C5, Anti-DDK monoclonal antibody, 100µl $248 In Stock
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0 2 weeks
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TrueORF Data for RC600031
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Vector: pCMV6-XL5-DDK-His   Change vector? Tag: C-terminal DDK-His
Sequence Data: ORF Nucleotide Sequence
Protein Sequence
ORF Size: 2850 bp
Predicted Protein MW: 106.8 kDa
Restriction Sites: SgfI-MluI     Cloning Scheme for this gene     Plasmid Map
OTI Annotation: This clone was engineered to express the extra cellular domain of the protein with an expression tag. Expression varies depending on the nature of the gene.
OTI Disclaimer: The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
Product Components: The ORF clone is ion-exchange column purified, transfection-ready dried plasmid DNA, and shipped with 2 vector sequencing primers.
Protein Families: Protein KinaseTransmembraneDruggable Genome
Protein Pathways: Cytokine-cytokine receptor interactionEndocytosisAxon guidanceFocal adhesionAdherens junctionEpithelial cell signaling in Helicobacter pylori infectionMore Pathways >>

Reference Data
RefSeq Explanation: NM_001127500.1 , NP_001120972
Synonyms: AUTS9; c-Met; DFNB97; HGFR; RCCP2 RefSeq Size: 6695 RefSeq ORF: 4227
LocusID: 4233 Cytogenetic: 7q31.2
Gene Summary: This gene encodes a member of the receptor tyrosine kinase family of proteins and the product of the proto-oncogene MET. The encoded preproprotein is proteolytically processed to generate alpha and beta subunits that are linked via disulfide bonds to form the mature receptor. Further processing of the beta subunit results in the formation of the M10 peptide, which has been shown to reduce lung fibrosis. Binding of its ligand, hepatocyte growth factor, induces dimerization and activation of the receptor, which plays a role in cellular survival, embryogenesis, and cellular migration and invasion. Mutations in this gene are associated with papillary renal cell carcinoma, hepatocellular carcinoma, and various head and neck cancers. Amplification and overexpression of this gene are also associated with multiple human cancers. [provided by RefSeq, May 2016].

 

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