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Home cDNA Clone TrueORF All LIPA ORF Clones
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LIPA (NM_000235) Human cDNA ORF Clone

Specifications Citations Clones of Other Species Product Documents
Cat. No. Description Price Availability  
RC201637 LIPA (Myc-DDK-tagged)-Human lipase A, lysosomal acid, cholesterol esterase (LIPA), transcript variant 2, 10µg   
$560
In Stock
RG201637 LIPA (GFP-tagged) - Human lipase A, lysosomal acid, cholesterol esterase (LIPA), transcript variant 2 $610 In Stock
TA50011-100 4C5, Anti-DDK monoclonal antibody, 100µl $248 In Stock
Cat. No. Description Price Availability
RC501637 LIPA (Myc-DDK-tagged)-Human lipase A, lysosomal acid, cholesterol esterase (LIPA), transcript variant 2, (200ug) $680 2 weeks
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The same insert cloned in a GFP-tagging vector is also available

Cat. No. Description Vector Price Availability  
RG201637 LIPA (GFP-tagged) - Human lipase A, lysosomal acid, cholesterol esterase (LIPA), transcript variant 2

$610 In Stock
TA150041 2H8, Anti-tGFP monoclonal antibody, 100µl Datasheet $248 In Stock
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TrueORF Data for RC201637
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Vector: pCMV6-Entry   Change vector? Tag: C-terminal Myc-DDK
Western validation with an anti-DDK antibody *
L: Control HEK293 lysate
R: Over-expression lysate
Lysate_Image
Sequence Data: ORF Nucleotide Sequence
Protein Sequence
ORF Size: 1197 bp
Predicted Protein MW: 45.43 kDa
Restriction Sites: SgfI-MluI     Cloning Scheme for this gene     Plasmid Map Plasmid Map
OTI Annotation: This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.
OTI Disclaimer: Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery.

The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
Product Components: The ORF clone is ion-exchange column purified, transfection-ready dried plasmid DNA, and shipped with 2 vector sequencing primers.
Protein Families: Druggable Genome
Protein Pathways: Steroid biosynthesisLysosome
* The lysates used for this WB picture contain the overexpressed empty vector or the Myc-DDK tagged ORF clone.

Reference Data
RefSeq Explanation: NM_000235.1 NM_000235.2 NM_000235.3 , NP_000226
Synonyms: CESD; LAL RefSeq Size: 2654 RefSeq ORF: 1200
LocusID: 3988 Cytogenetic: 10q23.31 Domains: abhydrolase, abhydro_lipase
Gene Summary: Crucial for the intracellular hydrolysis of cholesteryl esters and triglycerides that have been internalized via receptor-mediated endocytosis of lipoprotein particles. Important in mediating the effect of LDL (low density lipoprotein) uptake on suppression of hydroxymethylglutaryl-CoA reductase and activation of endogenous cellular cholesteryl ester formation. [UniProtKB/Swiss-Prot Function]

 

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