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Home cDNA Clone TrueORF All RASSF1 ORF Clones

RASSF1 (NM_007182) Human Mutant ORF Clone

Specifications Citations Clones of Other Species Product Documents
Cat. No. Description Price Availability  
RC402812 RASSF1 Mutant (A133S), Myc-DDK-tagged ORF clone of Homo sapiens Ras association (RalGDS/AF-6) domain family member 1 (RASSF1), transcript variant A as transfection-ready DNA, 10µg
$510
In Stock
TA50011-100 4C5, Anti-DDK monoclonal antibody, 100µl $248 In Stock
Clone Modification
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Also for RASSF1 (NM_007182)
cDNA Clone shRNA/siRNA Lysate Protein Request Antibody
TrueORF Data for RC402812
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Vector: pCMV6-Entry   Change vector? Tag: C-terminal Myc-DDK
Sequence Data: ORF Nucleotide Sequence
Protein Sequence
ORF Size: 1020 bp
Predicted Protein MW: 37.399999999999999 kDa
Restriction Sites: SgfI-MluI     Cloning Scheme for this gene     Plasmid Map
OTI Annotation:
OTI Disclaimer: The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
Product Components: The ORF clone is ion-exchange column purified, transfection-ready dried plasmid DNA, and shipped with 2 vector sequencing primers.
Protein Families: Druggable Genome
Protein Pathways: Pathways in cancerBladder cancerNon-small cell lung cancer
* The lysates used for this WB picture contain the overexpressed empty vector or the Myc-DDK tagged ORF clone.

Reference Data
RefSeq: , NP_009113
RefSeq Size: 1020 RefSeq ORF: 1023
Synonyms : 123F2; NORE2A; RASSF1A; RDA32; REH3P21
LocusID: 11186 Cytogenetic: 3p21.3 Domains: RA, DAG_PE-bind
Summary: This gene encodes a protein similar to the RAS effector proteins. Loss or altered expression of this gene has been associated with the pathogenesis of a variety of cancers, which suggests the tumor suppressor function of this gene. The inactivation of this gene was found to be correlated with the hypermethylation of its CpG-island promoter region. The encoded protein was found to interact with DNA repair protein XPA. The protein was also shown to inhibit the accumulation of cyclin D1, and thus induce cell cycle arrest. Several alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, May 2011].

 

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