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Home cDNA Clone TrueORF All CDKN1B ORF Clones

CDKN1B (NM_004064) Human Mutant ORF Clone

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Cat. No. Description Price Availability  
RC402694 CDKN1B Mutant (E172K), Myc-DDK-tagged ORF clone of Homo sapiens cyclin-dependent kinase inhibitor 1B (p27, Kip1) (CDKN1B) as transfection-ready DNA, 10µg
$380
1-2 weeks
TA50011-100 4C5, Anti-DDK monoclonal antibody, 100µl $248 In Stock
Clone Modification
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Also for CDKN1B (NM_004064)
cDNA Clone shRNA/siRNA CRISPR KO Kit Protein Antibody
TrueORF Data for RC402694
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Vector: pCMV6-Entry   Change vector? Tag: C-terminal Myc-DDK
Sequence Data: ORF Nucleotide Sequence
Protein Sequence
ORF Size: 594 bp
Predicted Protein MW: 21.8 kDa
Restriction Sites: SgfI-MluI     Cloning Scheme for this gene     Plasmid Map
OTI Annotation:
OTI Disclaimer: Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery.

The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
Product Components: The ORF clone is ion-exchange column purified, transfection-ready dried plasmid DNA, and shipped with 2 vector sequencing primers.
Protein Families: Druggable Genome
Protein Pathways: ErbB signaling pathwayCell cyclePathways in cancerProstate cancerChronic myeloid leukemiaSmall cell lung cancer

Reference Data
RefSeq: , NP_004055
RefSeq Size: 594 RefSeq ORF: 597
Synonyms : CDKN4; KIP1; MEN1B; MEN4; P27KIP1
LocusID: 1027 Cytogenetic: 12p13.1-p12 Domains: CDI
Summary: This gene encodes a cyclin-dependent kinase inhibitor, which shares a limited similarity with CDK inhibitor CDKN1A/p21. The encoded protein binds to and prevents the activation of cyclin E-CDK2 or cyclin D-CDK4 complexes, and thus controls the cell cycle progression at G1. The degradation of this protein, which is triggered by its CDK dependent phosphorylation and subsequent ubiquitination by SCF complexes, is required for the cellular transition from quiescence to the proliferative state. Mutations in this gene are associated with multiple endocrine neoplasia type IV (MEN4). [provided by RefSeq, Apr 2014].

 

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