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Home cDNA Clone TrueORF All MYC ORF Clones

MYC (NM_002467) Human Mutant ORF Clone

Specifications Citations Clones of Other Species Product Documents
Cat. No. Description Price Availability  
RC402623 MYC Mutant (S303N), Myc-DDK-tagged ORF clone of Homo sapiens v-myc myelocytomatosis viral oncogene homolog (avian) (MYC) as transfection-ready DNA, 10µg
$680
1-2 weeks
TA50011-100 4C5, Anti-DDK monoclonal antibody, 100µl $248 In Stock
Clone Modification
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Also for MYC (NM_002467)
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TrueORF Data for RC402623
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Vector: pCMV6-Entry   Change vector? Tag: C-terminal Myc-DDK
Sequence Data: ORF Nucleotide Sequence
Protein Sequence
ORF Size: 1362 bp
Predicted Protein MW: 49.899999999999999 kDa
Restriction Sites: SgfI-MluI     Cloning Scheme for this gene     Plasmid Map
OTI Annotation:
OTI Disclaimer: The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
Product Components: The ORF clone is ion-exchange column purified, transfection-ready dried plasmid DNA, and shipped with 2 vector sequencing primers.
Protein Families: Stem cell relevant signaling - JAK/STAT signaling pathwayStem cell relevant signaling - TGFb/BMP signaling pathwayStem cell relevant signaling - Wnt Signaling pathwayStem cell - PluripotencyEmbryonic stem cellsInduced pluripotent stem cellsTranscription FactorsDruggable Genome
Protein Pathways: MAPK signaling pathwayErbB signaling pathwayCell cycleWnt signaling pathwayTGF-beta signaling pathwayJak-STAT signaling pathwayMore Pathways >>
* The lysates used for this WB picture contain the overexpressed empty vector or the Myc-DDK tagged ORF clone.

Reference Data
RefSeq: , NP_002458
RefSeq Size: 1362 RefSeq ORF: 1362
Synonyms : bHLHe39; c-Myc; MRTL; MYCC
LocusID: 4609 Cytogenetic: 8q24.21 Domains: HLH, Myc_N_term, Myc-LZ
Summary: The protein encoded by this gene is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. It functions as a transcription factor that regulates transcription of specific target genes. Mutations, overexpression, rearrangement and translocation of this gene have been associated with a variety of hematopoietic tumors, leukemias and lymphomas, including Burkitt lymphoma. There is evidence to show that alternative translation initiations from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site result in the production of two isoforms with distinct N-termini. The synthesis of non-AUG initiated protein is suppressed in Burkitt's lymphomas, suggesting its importance in the normal function of this gene. [provided by RefSeq, Jul 2008].

 

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