Home All Cancer Mutant Clones TP53 Mutants

Description of the mutations of TP53 (NM_000546) Mutants

Reference:

95 Driver mutations in TP53 are ubiquitous in high grade serous carcinoma of the ovary
J. Pathol. 2010; 221: 49-56

Keys for Mutation Description

A.A. substitution
Truncation
NT deletion
NT insertion

R280G: Arg at aa-position 280 mutated to Gly
R342X: R at aa-position 342 mutated to a stop codon and caused truncation of the protein
N268_D2: The deletion starts at nt#268. Two bases (including nt268) are deleted
N478-I6: The insertion starts after nt#478. Six bases are inserted

SKU	Mutation Description	Affected Exon/Intron	Affected Codon#	Affected NT#	Description	Effect	Affected Protein Domain
RC400001	N258-D13	4-exon	86	c.258	del13	Frame Shift	proline-rich
RC400002	N292-D1	4-exon	98	c.292	del4	Frame Shift	N/A
RC400003	N542-D24	5-exon	181	c.542	del24	Frame Shift	DNA binding
RC400004	N683-D4	7-exon	228	c.683	del4	Frame Shift	DNA binding
RC400005	N715-D7	7-exon	239	c.715	del7	Frame Shift	DNA binding
RC400006	N764-D25I1	7-exon	255	c.764	del25ins1	Frame Shift	DNA binding
RC400007	N783-D15	7-exon/Int	261	c.783-12	del15	Frame Shift	DNA binding
RC400008	N868-D1	8-exon	290	c.868	del4	Frame Shift	DNA binding
RC400009	N1024-D10	10-exon	342	c.1024	del10	Frame Shift	oligomerisation
RC400010	N322-D6	4-exon	108	c.322	del6	other	DNA binding
RC400011	N478-I6	5-exon	160	c.478	ins6	other	DNA binding
RC400012	N206-D1	4-exon	69	c.206	del1	Frame Shift	proline-rich
RC400013	N268_D2	4-exon	90	c.268	del2	Frame Shift	proline-rich
RC400014	N286-D1	4-exon	96	c.286	del1	Frame Shift	proline-rich
RC400015	N342-I2	4-exon	114	c.342	ins1	Frame Shift	DNA binding
RC400016	N365-D2	4-exon	122	c.365	del2	Frame Shift	DNA binding
RC400017	N393-D1	5-exon	131	c.393	del1	Frame Shift	DNA binding
RC400018	N439-D1	5-exon	147	c.439	del1	Frame Shift	DNA binding
RC400019	N443-D2	5-exon	148	c.443	del2	Frame Shift	DNA binding
RC400020	N590-D1	6-exon	197	c.590	del1	Frame Shift	DNA binding
RC400021	N610-D1	6-exon	204	c.610	del1	Frame Shift	DNA binding
RC400022	N634-D1	6-exon	212	c.636	del1	Frame Shift	DNA binding
RC400023	N747-D1	7-exon	249	c.747	del1	Frame Shift	DNA binding
RC400024	N887-D1	8-exon	296	c.887	del1	Frame Shift	N/A
RC400025	N1039-D1	10-exon	347	c.1039	del1	Frame Shift	oligomerisation
RC400026	N887-D12I1	8-exon	296	c.887	del2ins1	Frame Shift	N/A
RC400027	Y107D	4-exon	107	c.319	T to G	missense	DNA binding
RC400028	C124X	4-exon	124	c.371	GC to AA	nonsense	DNA binding
RC400029	S127P	5-exon	127	c.379	T to C	missense	DNA binding
RC400030	L130H	5-exon	130	c.389	T to A	missense	DNA binding
RC400031	C141Y	5-exon	141	c.422	G to A	missense	DNA binding
RC400032	P151S	5-exon	151	c.451	C to T	missense	DNA binding
RC400033	P151H	5-exon	151	c.452	C to A	missense	DNA binding
RC400034	V157F	5-exon	157	c.469	G to T	missense	DNA binding
RC400035	Y163H	5-exon	163	c.487	T to C	missense	DNA binding
RC400036	Y163D	5-exon	163	c.487	T to G	missense	DNA binding
RC400037	Y163C	5-exon	163	c.488	A to G	missense	DNA binding
RC400038	H168P	5-exon	168	c.503	A to C	missense	DNA binding
RC400039	V173M	5-exon	173	c.517	G to A	missense	DNA binding
RC400040	R175H	5-exon	175	c.524	G to A	missense	DNA binding
RC400041	H178P	5-exon	178	c.533	A to C	missense	DNA binding
RC400042	H179R	5-exon	179	c.536	A to G	missense	DNA binding
RC400043	H179Q	5-exon	179	c.537	T to A	missense	DNA binding
RC400044	H193R	6-exon	193	c.578	A to G	missense	DNA binding
RC400045	I195N	6-exon	195	c.584	T to A	missense	DNA binding
RC400046	I195T	6-exon	195	c.584	T to C	missense	DNA binding
RC400047	Y205C	6-exon	205	c.614	A to G	missense	DNA binding
RC400048	S215I	6-exon	215	c.644	G to T	missense	DNA binding
RC400049	S215R	6-exon	215	c.645	T to G	missense	DNA binding
RC400050	V218G	6-exon	218	c.653	T to G	missense	DNA binding
RC400051	Y220H	6-exon	220	c.658	T to C	missense	DNA binding
RC400052	Y220C	6-exon	220	c.659	A to G	missense	DNA binding
RC400053	Y234C	7-exon	234	c.701	A to G	missense	DNA binding
RC400054	C238G	7-exon	238	c.712	T to G	missense	DNA binding
RC400055	C238Y	7-exon	238	c.713	G to A	missense	DNA binding
RC400056	S241Y	7-exon	241	c.722	C to A	missense	DNA binding
RC400057	S241F	7-exon	241	c.722	C to T	missense	DNA binding
RC400058	G245S	7-exon	245	c.733	G to A	missense	DNA binding
RC400059	G245D	7-exon	245	c.734	G to A	missense	DNA binding
RC400060	G245V	7-exon	245	c.734	G to T	missense	DNA binding
RC400061	M246V	7-exon	246	c.736	A to G	missense	DNA binding
RC400062	R248G	7-exon	248	c.742	C to G	missense	DNA binding
RC400063	R248W	7-exon	248	c.742	C to T	missense	DNA binding
RC400064	R248Q	7-exon	248	c.743	G to A	missense	DNA binding
RC400065	R249G	7-exon	249	c.745	A to G	missense	DNA binding
RC400066	R249M	7-exon	249	c.746	G to T	missense	DNA binding
RC400067	L257Q	7-exon	257	c.770	T to A	missense	DNA binding
RC400068	L257P	7-exon	257	c.770	T to C	missense	DNA binding
RC400069	E258K	7-exon	258	c.772	G to A	missense	DNA binding
RC400070	D259Y	7-exon	259	c.775	G to T	missense	DNA binding
RC400071	V272M	8-exon	272	c.814	G to A	missense	DNA binding
RC400072	R273C	8-exon	273	c.817	C to T	missense	DNA binding
RC400073	R273H	8-exon	273	c.818	G to A	missense	DNA binding
RC400074	R273L	8-exon	273	c.818	G to T	missense	DNA binding
RC400075	V274F	8-exon	274	c.820	G to T	missense	DNA binding
RC400076	C275Y	8-exon	275	c.824	G to A	missense	DNA binding
RC400077	P278S	8-exon	278	c.832	C to T	missense	DNA binding
RC400078	R280G	8-exon	280	c.838	A to G	missense	DNA binding
RC400079	D281G	8-exon	281	c.842	A to G	missense	DNA binding
RC400080	R282W	8-exon	282	c.844	C to T	missense	DNA binding
RC400081	E286K	8-exon	286	c.856	G to A	missense	DNA binding
RC400082	C141X	5-exon	141	c.423	C to A	nonsense	DNA binding
RC400083	Q165X	5-exon	165	c.493	C to T	nonsense	DNA binding
RC400084	Q167X	5-exon	167	c.499	C to T	nonsense	DNA binding
RC400085	Q192X	6-exon	192	c.574	C to T	nonsense	DNA binding
RC400086	R213X	6-exon	213	c.637	C to T	nonsense	DNA binding
RC400087	K291X	8-exon	291	c.871	A to T	nonsense	DNA binding
RC400088	K292X	8-exon	292	c.874	A to T	nonsense	DNA binding
RC400089	R306X	8-exon	306	c.916	C to T	nonsense	N/A
RC400090	R342X	10-exon	342	c.1024	C to T	nonsense	oligomerisation
RC400091	E343X	10-exon	343	c.1027	G to T	nonsense	oligomerisation
RC400092	E349X	10-exon	349	c.1045	G to T	nonsense	oligomerisation
RC400093	N681-I1	7-exon	227	c.681	ins1	Frame Shift	DNA binding
RC400094	N731-D1	7-exon	244	c.731	del1	Frame Shift	DNA binding
RC400095	N536-D13I1	5-exon	180	c.538	del3ins1	Frame Shift	DNA binding

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Description of the mutations of TP53 (NM_000546) Mutants