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HomeAll Cancer Mutant ClonesMPL Mutants

Description of the mutations of MPL (NM_005373) Mutants

Keys for Mutation Description

A.A. substitution
Truncation
NT deletion
NT insertion
R280G: Arg at aa-position 280 mutated to Gly
R342X: R at aa-position 342 mutated to a stop codon and caused truncation of the protein
N268_D2: The deletion starts at nt#268. Two bases (including nt268) are deleted
N478-I6: The insertion starts after nt#478. Six bases are inserted

 

SKUMutation DescriptionAffected Codon#Affected NT#DescriptionEffect
RC400169 W515K515c.1543_1544TG>AAMissense
RC400170 W515L515c.1544G>TMissense
RC400171 S505N505c.1514G>AMissense
RC400172 K39N39c.117G>CMissense

 

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