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HomeAll Cancer Mutant ClonesKRAS Mutants

Description of the mutations of KRAS (NM_004985) Mutants

Reference:

Germline KRAS mutations cause aberrant biochemical and physical properties leading to developmental disorders.
Hum. Mutat. 2011; 32:33-43

Keys for Mutation Description

A.A. substitution
Truncation
NT deletion
NT insertion
R280G: Arg at aa-position 280 mutated to Gly
R342X: R at aa-position 342 mutated to a stop codon and caused truncation of the protein
N268_D2: The deletion starts at nt#268. Two bases (including nt268) are deleted
N478-I6: The insertion starts after nt#478. Six bases are inserted

 

SKUMutation DescriptionAffected Codon#Affected NT#DescriptionEffectAffected Protein Domain
RC400104 G12D12c.35G>AmissenseGTP binding
RC400105 G12S12c.34G>AmissenseGTP binding
RC400106 G12R12c.34G>CmissenseGTP binding
RC400107 G12C12c.34G>TmissenseGTP binding
RC400108 G12A12c.35G>CmissenseGTP binding
RC400109 G12V12c.35G>TmissenseGTP binding
RC400110 G12F12c.34-35GG>TTmissenseGTP binding
RC400111 A59T59c.175G>AmissenseGTP binding
RC400112 Q61H61c.183A>C/TmissenseGTP binding
RC400113 Q61L61c.182A>TmissenseGTP binding
RC400114 Q61R61c.182A>GmissenseGTP binding
RC400115 Q61E61c.181C>GmissenseGTP binding
RC400116 G13D13c.38G>AmissenseGTP binding
RC400117 G13C13c.37G>TmissenseGTP binding
RC400118 G13A13c.38G>CmissenseGTP binding
RC400119 G13S13c.37G>AmissenseGTP binding
RC400120 G13V13c.38G>TmissenseGTP binding
RC400121 G13R13c.37G>CmissenseGTP binding
RC400122 L19F19c.57G>CmissenseGTP binding
RC400123 Q22K22c.64C>AmissenseGTP binding
RC400124 A146T146c.436G>AmissenseGTP binding

 

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