Silencing hsp25/hsp27 Gene Expression Augments Proteasome Activity and Increases CD8+ T-Cell–Mediated Tumor Killing and Memory Responses
Cancer Prevention Research, Jan 2012; 5: 122 - 137.
[HSPB1
]
Activation of Androgen Receptor, Lipogenesis, and Oxidative Stress Converged by SREBP-1 Is Responsible for Regulating Growth and Progression of Prostate Cancer Cells
Mol. Cancer Res., Jan 2012; 10: 133 - 142.
[SREBF1
]
Androgen Deprivation Causes Epithelial–Mesenchymal Transition in the Prostate: Implications for Androgen-Deprivation Therapy
Cancer Res., Jan 2012; 72: 527 - 536.
[AR
]
CB2 Cannabinoid Receptors Promote Neural Progenitor Cell Proliferation via mTORC1 Signaling
J. Biol. Chem., Jan 2012; 287: 1198 - 1209.
[Cnr2
]
MicroRNAs (miRNAs) are naturally occurring non-coding RNAs of 21-23 nt and they have been implicated in many biological processes and disease development. MiRNA are processed in multiple steps:
DNA→ Pri-miRNA → Pre-miRNA→ Mature miRNA
OriGene provides clones for over-expression of miRNA of your choice. A region of ~600bp region encompassing each miRNA is cloned downstream of a CMV promoter. Upon transfection, the cellular machinery will process the CMV-driven expression of miRNA precursor into mature miRNA and cellular function can be analyzed.
Genome wide miRNA coverage (miRBase release 13.0) - 652 human and 486 mouse
GFP as reporter for transfection monitoring
Neomycin selection marker for stable cell establishment
10 μg transfection-ready DNA using PowerPrep® HP Kits
