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OriGene Antibodies in recent publications
Extraordinary response to crizotinib in a woman with squamous cell lung cancer after two courses of failed chemotherapy BMC Pulm Med Jun 2014 []

A novel protein is lower expressed in renal cell carcinoma Int J Mol Sci May 2014 []

Aberrantly Over-Expressed TRPM8 Channels in Pancreatic Adenocarcinoma: Correlation with Tumor Size/Stage and Requirement for Cancer Cells Invasion Cells May 2014 []

An Aberrant Leukotriene A4 Hydrolase-PGP Pathway in the Pathogenesis of Chronic Obstructive Pulmonary Disease Am. J. Respir. Crit. Care Med. May 2014 []

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TruePLEX™ PDGF-BB Single-plex Reagent Set

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AM100099 TruePLEX™ PDGF-BB Single-plex Reagent Set (Gene ID: 5155) 96 rxn $229 2 weeks
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Product Details: Single-plex reagent set for the measurement of PDGF-BB heterodimer in cell culture supernatant, human sera, or human plasma in conjunction with xMAP™ technology from Luminex Corporation. These reagents may be combined with other Growth Factor Panel single-plex reagent sets to create a custom multiplex. The TruePLEX™ Extracellular Core Reagent Kit (AM100097) kit is required to run this assay.
Standard Curves
11 plex standard curves
Gene Name: Platelet-derived growth factor beta polypeptide
Research Focus: Oncology
Platform: Luminex xMAP®
Product Configuration: Single-plex can be mixed with up to 9 other single-plexes
Product Type: Single-plex reagent set
Sample Type: serum, plasma, tissue culture supernatant
Sample Volume: 50 µl
Species Reactivity: Human
Components: Beads, detection antibody, standards
Performance Summary
Performance Summary
Sensitivity Specification: 14 pg/ml
Normal Mean and Range Serum Samples: 1194.9 (29.7 - 5011)
Normal Mean and Range Plasma Samples: 434.6 (11.4 - 1756)
Intra-assay CV – Standards (specification): <15%
Intra-assay CV – Serum/Plasma (specification): <20%
Inter-assay CV – Serum/Plasma (specification): <20%
Recovery (specification) : 80-120%
Linearity (specification): 80-120%
Cross Reactivity: Negligible
Background Info: The protein encoded by this gene is a member of the platelet-derived growth factor family. The four members of this family are mitogenic factors for cells of mesenchymal origin and are characterized by a motif of eight cysteines. This gene product can exist either as a homodimer (PDGF-BB) or as a heterodimer with the platelet-derived growth factor alpha polypeptide (PDGF-AB), where the dimers are connected by disulfide bonds. Mutations in this gene are associated with meningioma. Reciprocal translocations between chromosomes 22 and 17, at sites where this gene and that for collagen type 1, alpha 1 are located, are associated with a particular type of skin tumor called dermatofibrosarcoma protuberans resulting from unregulated expression of growth factor. Two alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Feb 2013].
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