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Home TrueClone DCN Clone

DCN (NM_133506) Human cDNA Clone

Specifications Citations Clones of Other Species Product Documents
SKU Description Price Availibility*  
SC120507 DCN (untagged)-Human decorin (DCN), transcript variant D, NM_133506.2, 10ug $390 In Stock
TF81001 TurboFectin, High performance Transfection reagent (1ml/vial) $420 In Stock
TA305696 Goat Anti-Decorin Antibody, 100ug $325 3-7 Days
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OriGene Data
Vector: pCMV6-XL4 Insert Size: 2000 Restriction Site: NotI-NotI
Sequence Data: Fully Sequenced ORF          5' Read Nucleotide Sequence         
OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Product Components: The cDNA clone is shipped in a 2-D bar-coded Matrix tube as dried plasmid DNA. The package also includes 100 pmols of both the corresponding 5' and 3' vector primers in separate vials. Every lot of primer is tested to provide clean sequencing of OriGene TrueClones.
Protein Families: Secreted ProteinDruggable Genome
Protein Pathways: TGF-beta signaling pathway
Reference Data
RefSeq Explanation: NM_133506.2, NP_598013
RefSeq Size: 1336 RefSeq ORF: 519
Synonyms : CSCD; DSPG2; PG40; PGII; PGS2; SLRR1B
LocusID: 1634 Cytogenetic: 12q21.33 Domains: LRRNT, LRR
Gene Summary: This gene encodes a member of the small leucine-rich proteoglycan family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature protein. This protein plays a role in collagen fibril assembly. Binding of this protein to multiple cell surface receptors mediates its role in tumor suppression, including a stimulatory effect on autophagy and inflammation and an inhibitory effect on angiogenesis and tumorigenesis. This gene and the related gene biglycan are thought to be the result of a gene duplication. Mutations in this gene are associated with congenital stromal corneal dystrophy in human patients. [provided by RefSeq, Nov 2015].

Transcript Variant: This variant (D) lacks exons 4, 5, 6 and 7 in the coding region compared to variant A1. This does not cause a frameshift but the encoded isoform d lacks an internal 187 amino acids. Thus it is not clear if cleavage takes place for the mature peptide to be produced from the proprotein.

* Delivery time is an estimate in business days. Occasional delays may occur due to unforeseen complexities in the preparation of your construct. International customers may expect an additional 1-2 weeks in shipping

 

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