Over 1000 citations of OriGene cDNA clones

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Tumor Lymphangiogenesis and Metastasis to Lymph Nodes Induced by Cancer Cell Expression of Podoplanin Am. J. Pathol., Aug 2010; 177: 1004 - 1016 [PDPN]

AML1 is overexpressed in patients with myeloproliferative neoplasms and mediates JAK2V617F-independent overexpression of NF-E2 Blood, Jul 2010; 116: 254 - 266 [RUNX1]

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UPF3A (NM_023011) Human cDNA Clone

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Cat. No.

Ref. ID

Description

Amount

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SC305068

NM_023011

Homo sapiens UPF3 regulator of nonsense transcripts homolog A (yeast) (UPF3A), transcript variant 1 as transfection-ready DNA NM_023011.2

$700

4-5 weeks

Also for UPF3A (NM_023011)

OriGene TrueClone Data

Vector:	pCMV6-XL	Insert Size:	Restriction Site:
Sequence Data:	Edited Nucleotide Sequence 5' Read Nucleotide Sequence
OTI Annotation:	This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA
OTI Disclaimer:	Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Product Components:	The cDNA clone is shipped in a 2-D bar-coded Matrix tube as dried plasmid DNA. The package also includes 100 pmols of both the corresponding 5' and 3' vector primers in separate vials. Every lot of primer is tested to provide clean sequencing of OriGene TrueClones.

Reference Data

RefSeq: NM_023011.2, NP_075387	RefSeq Size: 2381	RefSeq ORF: 1431
Synonyms : HUPF3A; RENT3A; UPF3
LocusID: 65110	Cytogenetic: 13q34
Summary: This gene encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. The encoded protein is one of two functional homologs to yeast Upf3p. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein binds to the mRNA and remains bound after nuclear export, acting as a nucleocytoplasmic shuttling protein. It forms with Y14 a complex that binds specifically 20 nt upstream of exon-exon junctions. This gene is located on the long arm of chromosome 13. Two splice variants encoding different isoforms have been found for this gene. [provided by RefSeq]. Transcript Variant: This variant (1) is the full-length transcript and encodes the longer isoform (Upf3p).