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Home TrueClone HLA Clone

HLA (NM_018950) Human cDNA Clone

Specifications Citations Clones of Other Species Product Documents
SKU Description Price Availibility*  
SC127080 HLA (untagged)-Human major histocompatibility complex, class I, F (HLA-F), transcript variant 2 (10ug), NM_018950.1, 10ug $520 In Stock
TF81001 TurboFectin, High performance Transfection reagent (1ml/vial) $420 In Stock
TA310580 Rabbit Monoclonal antibody against HLA-F, 100ul $325 3-7 Days
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OriGene Data
Vector:pCMV6-XL5 Insert Size: 1140 Restriction Site: NotI-NotI
Sequence Data: Fully Sequenced ORF          5' Read Nucleotide Sequence          3' Read Nucleotide Sequence         
OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Product Components: The cDNA clone is shipped in a 2-D bar-coded Matrix tube as dried plasmid DNA. The package also includes 100 pmols of both the corresponding 5' and 3' vector primers in separate vials. Every lot of primer is tested to provide clean sequencing of OriGene TrueClones.
Protein Families: Transmembrane
Protein Pathways: EndocytosisCell adhesion molecules (CAMs)Antigen processing and presentationType I diabetes mellitusAutoimmune thyroid diseaseAllograft rejectionMore Pathways >>
Reference Data
RefSeq: NM_018950.1, NP_061823
RefSeq Size: 1301 RefSeq ORF: 1041
Synonyms : CDA12; HLA-5.4; HLA-CDA12; HLAF
LocusID: 3134 Cytogenetic: 6p21.3 Domains: MHC_I, ig, IGc1
Summary: This gene belongs to the HLA class I heavy chain paralogues. It encodes a non-classical heavy chain that forms a heterodimer with a beta-2 microglobulin light chain, with the heavy chain anchored in the membrane. Unlike most other HLA heavy chains, this molecule is localized in the endoplasmic reticulum and Golgi apparatus, with a small amount present at the cell surface in some cell types. It contains a divergent peptide-binding groove, and is thought to bind a restricted subset of peptides for immune presentation. This gene exhibits few polymorphisms. Multiple transcript variants encoding different isoforms have been found for this gene. These variants lack a coding exon found in transcripts from other HLA paralogues due to an altered splice acceptor site, resulting in a shorter cytoplasmic domain. [provided by RefSeq, Jul 2008].

Transcript Variant: This variant (2) uses an alternate 3' exon, compared to variant 1. The resulting isoform (2) has a shorter and distinct C-terminus, compared to isoform 1.

* Delivery time is an estimate in business days. Occasional delays may occur due to unforeseen complexities in the preparation of your construct. International customers may expect an additional 1-2 weeks in shipping

 

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