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Home TrueClone NRG1 Clone

NRG1 (NM_013964) Human cDNA Clone

Specifications Citations Clones of Other Species Product Documents
SKU Description Price Availibility*  
SC124811 NRG1 (untagged)-Human neuregulin 1 (NRG1), transcript variant HRG-alpha (10ug) NM_013964.1, 10ug $680 In Stock
TF81001 TurboFectin, High performance Transfection reagent (1ml/vial) $420 In Stock
TA311659 Rabbit polyclonal NRG1 isoform-10 antibody, 100ul $325 In Stock
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OriGene Data
Vector:pCMV6-XL5 Insert Size: 5700 Restriction Site:
Sequence Data: Fully Sequenced ORF          5' Read Nucleotide Sequence         
OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Product Components: The cDNA clone is shipped in a 2-D bar-coded Matrix tube as dried plasmid DNA. The package also includes 100 pmols of both the corresponding 5' and 3' vector primers in separate vials. Every lot of primer is tested to provide clean sequencing of OriGene TrueClones.
Protein Families: Secreted ProteinTransmembraneTranscription FactorsDruggable Genome
Protein Pathways: ErbB signaling pathway
Reference Data
RefSeq: NM_013964.1, NP_039258
RefSeq Size: 3078 RefSeq ORF: 1923
Synonyms : ARIA; GGF; GGF2; HGL; HRG; HRG1; HRGA; MST131; NDF; SMDF
LocusID: 3084 Cytogenetic: 8p12
Summary: The protein encoded by this gene was originally identified as a 44-kD glycoprotein that interacts with the NEU/ERBB2 receptor tyrosine kinase to increase its phosphorylation on tyrosine residues. This protein is a signaling protein that mediates cell-cell interactions and plays critical roles in the growth and development of multiple organ systems. It is known that an extraordinary variety of different isoforms are produced from this gene through alternative promoter usage and splicing. These isoforms are tissue-specifically expressed and differ significantly in their structure, and thereby these isoforms are classified into types I, II, III, IV, V and VI. The gene dysregulation has been linked to diseases such as cancer, schizophrenia and bipolar disorder (BPD). [provided by RefSeq, May 2009].

Transcript Variant: This variant (HRG-alpha, also called erbB2) has an alternate internal segment, compared to variant HRG-beta1. The resulting isoform (HRG-alpha) is shorter, and has identical N- and C-termini and a different internal segment, compared to isoform HRG-beta1.

* Delivery time is an estimate in business days. Occasional delays may occur due to unforeseen complexities in the preparation of your construct. International customers may expect an additional 1-2 weeks in shipping

 

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