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Home TrueClone TXNRD2 Clone

TXNRD2 (NM_006440) Human cDNA Clone

Specifications Citations (1) Clones of Other Species Product Documents
SKU Description Price Availibility*  
SC116122 TXNRD2 (untagged)-Human thioredoxin reductase 2 (TXNRD2), nuclear gene encoding mitochondrial protein (10ug), (Note: selenocysteine protein, Internal stop codon present. see reference data summary below), NM_006440.2, 10ug $810 In Stock
TF81001 TurboFectin, High performance Transfection reagent (1ml/vial) $420 In Stock
TA311671 Rabbit polyclonal anti-TRXR2 antibody, 100ul $325 In Stock
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OriGene Data
Vector: pCMV6-XL4 Insert Size: 2000 Restriction Site: NotI-NotI
Sequence Data: Fully Sequenced ORF          5' Read Nucleotide Sequence          3' Read Nucleotide Sequence         
OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Product Components: The cDNA clone is shipped in a 2-D bar-coded Matrix tube as dried plasmid DNA. The package also includes 100 pmols of both the corresponding 5' and 3' vector primers in separate vials. Every lot of primer is tested to provide clean sequencing of OriGene TrueClones.
Protein Families: Druggable Genome
Protein Pathways: Pyrimidine metabolism
Reference Data
RefSeq Explanation: NM_006440.2, NP_006431
RefSeq Size: 2180 RefSeq ORF: 2127
Synonyms : SELZ; TR; TR-BETA; TR3; TRXR2
LocusID: 10587 Cytogenetic: 22q11.21 Domains: pyr_redox, pyr_redox_dim
Gene Summary: This gene encodes a member of the class I pyridine nucleotide-disulfide oxidoreductase family. The encoded protein is a selenocysteine-containing flavoenzyme that maintains thioredoxins in a reduced state, thereby playing a key role in regulating the cellular redox environment. Mammals have three related thioredoxin reductases. This gene encodes a mitochondrial form important for scavenging of reactive oxygen species in mitochondria. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Sep 2013].

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer protein (isoform 1). CCDS Note: This CCDS ID represents the protein described in PMIDs: 9923614 and 10215850. This transcript is supported by AF106697.1. It should be noted this transcript is predicted to undergo nonsense-mediated mRNA decay (NMD). However, the protein is represented because it was detected endogenously in PMID: 9923614. It is likely that the majority of transcripts representing this variant will undergo NMD, while some low level of NMD escape may allow for the expression of this protein.

* Delivery time is an estimate in business days. Occasional delays may occur due to unforeseen complexities in the preparation of your construct. International customers may expect an additional 1-2 weeks in shipping


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