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Home TrueClone LCK Clone

LCK (NM_005356) Human Kinase Deficient Mutant

Specifications Citations Clones of Other Species Product Documents
SKU Description Price Availibility*  
SC323616 LCK (untagged)-Kinase deficient mutant (K273M) of Human lymphocyte-specific protein tyrosine kinase (LCK), transcript variant 2 (10ug), NM_005356.2, 10ug $770 In Stock
TF81001 TurboFectin, High performance Transfection reagent (1ml/vial) $420 In Stock
TA300455 Rabbit Monoclonal Antibody against LCK (Clone Y123), 100ul $325 3-7 Days
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Click here for the corresponding wild type clone.

OriGene Data
Vector:pCMV6-XL6 Insert Size: 2740 Restriction Site:
Sequence Data: Fully Sequenced ORF          5' Read Nucleotide Sequence          Kinase domain sequence
OTI Annotation: This kinase-deficient mutant clone was generated by created by site-directed mutagenesis from the corresponding wild-type clone. See details in "Application of active and kinase-deficient kinome collection for identification of kinases regulating hedgehog signaling." Cell. 2008 May p536-548.
OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Product Components: The cDNA clone is shipped in a 2-D bar-coded Matrix tube as dried plasmid DNA. The package also includes 100 pmols of both the corresponding 5' and 3' vector primers in separate vials. Every lot of primer is tested to provide clean sequencing of OriGene TrueClones.
Protein Families: Protein KinaseStem cell - PluripotencyDruggable Genome
Protein Pathways: Natural killer cell mediated cytotoxicityT cell receptor signaling pathwayPrimary immunodeficiency
Reference Data
RefSeq: NM_005356.2, NP_005347
RefSeq Size: 2135 RefSeq ORF: 1530
Synonyms : IMD22; LSK; p56lck; pp58lck; YT16
LocusID: 3932 Cytogenetic: 1p34.3 Domains: pkinase, SH2, TyrKc, SH3, S_TKc
Summary:

Transcript Variant: This variant (2) is transcribed from the distal type II promoter and contains a distinct 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein.

* Delivery time is an estimate in business days. Occasional delays may occur due to unforeseen complexities in the preparation of your construct. International customers may expect an additional 1-2 weeks in shipping

 

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