ROR1 (NM_005012) Human Untagged Clone

CAT#: SC117005

ROR1 (untagged)-Human receptor tyrosine kinase-like orphan receptor 1 (ROR1), transcript variant 1

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: ROR1
• Synonyms: dJ537F10.1; NTRKR1
• Vector: pCMV6-XL6
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >OriGene ORF sequence for NM_005012 edited
  ATGCACCGGCCGCGCCGCCGCGGGACGCGCCCGCCGCTCCTGGCGCTGCTGGCCGCGCTG
  CTGCTGGCCGCACGCGGGGCTGCTGCCCAAGAAACAGAGCTGTCAGTCAGTGCTGAATTA
  GTGCCTACCTCATCATGGAACATCTCAAGTGAACTCAACAAAGATTCTTACCTGACCCTT
  GATGAACCAATGAATAACATCACCACGTCTCTGGGCCAGACAGCAGAACTGCACTGCAAA
  GTCTCTGGGAATCCACCTCCCACCATCCGCTGGTTCAAAAATGATGCTCCTGTGGTCCAG
  GAGCCCCGGAGGCTCTCCTTTCGGTCCACCATCTATGGCTCTCGGCTGCGGATTAGAAAC
  CTCGACACCACAGACACAGGCTACTTCCAGTGCGTGGCAACAAACGGCAAGGAGGTGGTT
  TCTTCCACTGGAGTCTTGTTTGTCAAGTTTGGCCCCCCTCCCACTGCAAGTCCAGGATAC
  TCAGATGAGTATGAAGAAGATGGATTCTGTCAGCCATACAGAGGGATTGCATGTGCAAGA
  TTTATTGGCAACCGCACCGTCTATATGGAGTCTTTGCACATGCAAGGGGAAATAGAAAAT
  CAGATCACAGCTGCCTTCACTATGATTGGCACTTCCAGTCACTTATCTGATAAGTGTTCT
  CAGTTCGCCATTCCTTCCCTGTGCCACTATGCCTTCCCGTACTGCGATGAAACTTCATCC
  GTCCCAAAGCCCCGTGACTTGTGTCGCGATGAATGTGAAATCCTGGAGAATGTCCTGTGT
  CAAACAGAGTACATTTTTGCAAGATCAAATCCCATGATTCTGATGAGGCTGAAACTGCCA
  AACTGTGAAGATCTCCCCCAGCCAGAGAGCCCAGAAGCTGCGAACTGTATCCGGATTGGA
  ATTCCCATGGCAGATCCTATAAATAAAAATCACAAGTGTTATAACAGCACAGGTGTGGAC
  TACCGGGGGACCGTCAGTGTGACCAAATCAGGGCGCCAGTGCCAGCCATGGAATTCCCAG
  TATCCCCACACACACACTTTCACCGCCCTTCGTTTCCCAGAGCTGAATGGAGGCCATTCC
  TACTGCCGCAACCCAGGGAATCAAAAGGAAGCTCCCTGGTGCTTCACCTTGGATGAAAAC
  TTTAAGTCTGATCTGTGTGACATCCCAGCTTGCGATTCAAAGGATTCCAAGGAGAAGAAT
  AAAATGGAAATCCTGTACATACTAGTGCCAAGTGTGGCCATTCCCCTGGCCATTGCTTTA
  CTCTTCTTCTTCATTTGCGTCTGTCGGAATAACCAGAAGTCATCGTCGGCACCAGTCCAG
  AGGCAACCAAAACACGTCAGAGGTCAAAATGTAGAGATGTCAATGCTGAATGCATATAAA
  CCCAAGAGCAAGGCTAAAGAGCTACCTCTTTCTGCTGTACGCTTTATGGAAGAATTGGGT
  GAGTGTGCCTTTGGAAAAATCTATAAAGGCCATCTCTATCTCCCAGGCATGGACCATGCT
  CAGCTGGTTGCTATCAAGACCTTGAAAGACTATAACAACCCCCAGCAATGGATGGAATTT
  CAACAAGAAGCCTCCCTAATGGCAGAACTGCACCACCCCAATATTGTCTGCCTTCTAGGT
  GCCGTCACTCAGGAACAACCTGTGTGCATGCTTTTTGAGTATATTAATCAGGGGGATCTC
  CATGAGTTCCTCATCATGAGATCCCCACACTCTGATGTTGGCTGCAGCAGTGATGAAGAT
  GGGACTGTGAAATCCAGCCTGGACCACGGAGATTTTCTGCACATTGCAATTCAGATTGCA
  GCTGGCATGGAATACCTGTCTAGTCACTTCTTTGTCCACAAGGACCTTGCAGCTCGCAAT
  ATTTTAATCGGAGAGCAACTTCATGTAAAGATTTCAGACTTGGGGCTTTCCAGAGAAATT
  TACTCCGCTGATTACTACAGGGTCCAGAGTAAGTCCTTGCTGCCCATTCGCTGGATGCCC
  CCTGAAGCCATCATGTATGGCAAATTCTCTTCTGATTCAGATATCTGGTCCTTTGGGGTT
  GTCTTGTGGGAGATTTTCAGTTTTGGACTCCAGCCATATTATGGATTCAGTAACCAGGAA
  GTGATTGAGATGGTGAGAAAACGGCAGCTCTTACCATGCTCTGAAGACTGCCCACCCAGA
  ATGTACAGCCTCATGACAGAGTGCTGGAATGAGATTCCTTCTAGGAGACCAAGATTTAAA
  GATATTCACGTCCGGCTTCGGTCCTGGGAGGGACTCTCAAGTCACACAAGCTCTACTACT
  CCTTCAGGGGGAAATGCCACCACACAGACAACCTCCCTCAGTGCCAGCCCAGTGAGTAAT
  CTCAGTAACCCCAGATATCCTAATTACATGTTCCCGAGCCAGGGTATTACACCACAGGGC
  CAGATTGCTGGTTTCATTGGCCCGCCAATACCTCAGAACCAGCGATTCATTCCCATCAAT
  GGATACCCAATACCTCCTGGATATGCAGCGTTTCCAGCTGCCCACTACCAGCCAACAGGT
  CCTCCCAGAGTGATTCAGCACTGCCCACCTCCCAAGAGTCGGTCCCCAAGCAGTGCCAGT
  GGGTCGACTAGCACTGGCCATGTGACTAGCTTGCCCTCATCAGGATCCAATCAGGAAGCA
  AATATTCCTTTACTACCACACATGTCAATTCCAAATCATCCTGGTGGAATGGGTATCACC
  GTTTTTGGCAACAAATCTCAAAAACCCTACAAAATTGACTCAAAGCAAGCATCTTTACTA
  GGAGACGCCAATATTCATGGACACACCGAATCTATGATTTCTGCAGAACTGTAA
  
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_005012 unedited
  ATCCTTCCCGCCCGTTGCCGCATTGGGCGGTAGGCGTGTACGGTGGGAAGGTCTATATAA
  GCAGAGCTCATTTAGGTGACACTATAGAATACAAGCTACTTGTTCTTTTTGCAGCGGCCG
  CGAATTCGGCACGAGGGAGCGTGGAGAGCTGGAGCAGCCGCCACCGCCGCCGCCGAGGGA
  GCCCCGGGACGGCAGCCCCTGGGCGCAGGGTGCGCTGTTCTCGGAGTCCGACCCAGGGCG
  ACTCACGCCCACTGGTGCGACCCGGACAGCCTGGGACTGACCCGCCGGCCCAGGCGAGGC
  TGCAGCCAGAGGGCTGGGAAGGGATCGCGCTCGCGGCATCCAGAGGCGGCCAGGCGGAGG
  CGAGGGAGCAGGTTAGAGGGACAAAGAGCTTTGCAGACGTCCCCGGCGTCCTGCGAGCGC
  CAGCGGCCGGGACGAGGCGGCCGGGAGCCCGGGAAGAGCCCGTGGATGTTCTGCGCGCGG
  CCTGGGAGCCGCCGCCGCCGCCGCCTCAGCGAGAGGAGGAATGCACCGGCCGCGCCGCCG
  CGGGACGCGCCCGCCGCTCCTGGCGCTGCTGGCCGCGCTGCTGCTGGCCGCACGCGGAGC
  TGCTGCCCAAGAAACAGAGCTGTCAGTCAGTGCTGAATTAGTGCCTACCTCATCATGGAA
  CATCTCAAGTGAACTCAACANAGATTCTTACCTGACCCTTGATGAACCAATGAATAACAT
  CACCACGTCTCTAGGCCAGACAGCAGAACTGCACTGCANAGTCTCTGGGAATCCACNNCT
  CCACATCCGCTGGGTCAAAAATGATGCTCCTGTGGTCCAGGAGCCCCGGAGGGCTCTCTT
  TCGTTCAACATCTATGGCTCTCGGCTGGCGGATTANAAACTCGACACCCCAGACCAAGCT
  ACTTTCAGTGCGTGGCAACA
  
  3' Read Nucleotide Sequence

  >OriGene 3' read for NM_005012 unedited
  AAATTCGCGGTGTCTGTCCCTGCTTGGTAAGACACATGNAACTTCACANAGGTACTTGTT
  GCGATGTCTGCTAAATGAGAACCTTACTTTAATAAAAACATTTGAATATAAATCTTTTCT
  ACGGCCGTCTAGTTTGTCCTGTATACCACATTTACAAAAGTTGTGCATTTTACAGTTCTG
  CAGAAATCATAGATTCGGTGTGTCCATGAATATTGGCGTCTCCTAGTAAAGATGCTTGCT
  TTGAGTCAATTTTGTAGGGTTTTTGAGATTTGTTGCCAACAACGGTGATACCCATTCCAC
  CAGGATGATTTGGAATTGACATGTGTGGTAGTAAAGGAATATTTGCTTCCTGATTGGATC
  CTGATGAGGGCAAGCTAGTCACATGGCCAGTGCTAGTCGACCCACTGGCACTGCTTGGGG
  ACCGACTCTTGGGAGGTGGGCAGTGCTGAATCACTCTGGGAGGACCTGTTGGCTGGTAGT
  GGGCAGCATGAAACGCTGCATATCCAGGAGGTATTGGGTATCCATTGATGGGAATGAATC
  GCTGGTTCTGAGGTATTGGCGGGCCAATGAAACCAGCCATCTGGCCCTGTGGTGTAATAC
  CCTGGCTCGGGAACATGTAATTAGGATATCTGGGGTTACTGAGATTACTCACTGNGCTGG
  CACTGAGGGAGGTTGTCTGTGTGGTGGCATTTCCCCCTGAAGGAGTAGTAGAGCTTGTGT
  GACTTGAGAGTCCCTNCCAGGACCGAAGCCCNACGTGAATATCTTTAAATCTTGGTCTTC
  TAGAAGGAATCTCATTCCAGCACTCTGTCATTGAGCTGTACATTCTGGGTGGGCAGTCTT
  CANAGCATGTTAAGAGCTGCCGNTTTCTCACCATCTCATCACTTTCTGGTTACTGAATCC
  ATATTATGG
  
• Restriction Sites: NotI-NotI
• ACCN: NM_005012
• Insert Size: 3500 bp
• OTI Disclaimer: Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery.
  
  The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• Product Components: The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
• Reconstitution: 1. Centrifuge at 5,000xg for 5min.
  2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
  3. Close the tube and incubate for 10 minutes at room temperature.
  4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
  5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.

Reference Data

• RefSeq: NM_005012.1, NP_005003.1
• RefSeq Size: 5871 bp
• RefSeq ORF: 2814 bp
• Locus ID: 4919
• UniProt ID: Q01973
• Cytogenetics: 1p31.3
• Domains: KR, FRI, pkinase, TyrKc, S_TKc, ig, IGc2, IG
• Protein Families: Druggable Genome, Protein Kinase, Transmembrane
• Gene Summary: This gene encodes a receptor tyrosine kinase-like orphan receptor that modulates neurite growth in the central nervous system. The encoded protein is a glycosylated type I membrane protein that belongs to the ROR subfamily of cell surface receptors. It is a pseudokinase that lacks catalytic activity and may interact with the non-canonical Wnt signalling pathway. This gene is highly expressed during early embryonic development but expressed at very low levels in adult tissues. Increased expression of this gene is associated with B-cell chronic lymphocytic leukaemia. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jun 2012]
  Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). Sequence Note: This RefSeq record was created from transcript and genomic sequence data because transcript sequence consistent with the reference genome assembly was not available for all regions of the RefSeq transcript. The extent of this transcript is supported by transcript alignments.