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Home TrueClone ERBB2 Clone

ERBB2 (NM_004448) Human Kinase Deficient Mutant

Specifications Citations Clones of Other Species Product Documents
SKU Description Price Availibility*  
SC323549 ERBB2 (untagged)-Kinase deficient mutant (K753M) of Human v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) (ERBB2), transcript variant 1 (10ug), NM_004448.2, 10ug $2260 In Stock
TF81001 TurboFectin, High performance Transfection reagent (1ml/vial) $420 In Stock
UM500036 Purified HER2 (ERBB2) mouse monoclonal antibody,clone UMAB36, 100ul $468 In Stock
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Click here for the corresponding wild type clone.

OriGene Data
Vector:pCMV6-XL4 Insert Size: 4000 Restriction Site:
Sequence Data: Fully Sequenced ORF          5' Read Nucleotide Sequence          Kinase domain sequence
OTI Annotation: This kinase-deficient mutant clone was generated by created by site-directed mutagenesis from the corresponding wild-type clone. See details in "Application of active and kinase-deficient kinome collection for identification of kinases regulating hedgehog signaling." Cell. 2008 May p536-548.
OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Product Components: The cDNA clone is shipped in a 2-D bar-coded Matrix tube as dried plasmid DNA. The package also includes 100 pmols of both the corresponding 5' and 3' vector primers in separate vials. Every lot of primer is tested to provide clean sequencing of OriGene TrueClones.
Protein Families: Protein KinaseTransmembraneDruggable Genome
Protein Pathways: ErbB signaling pathwayCalcium signaling pathwayFocal adhesionAdherens junctionPathways in cancerPancreatic cancerMore Pathways >>
Reference Data
RefSeq: NM_004448.2, NP_004439
RefSeq Size: 4624 RefSeq ORF: 3768
Synonyms : CD340; HER-2; HER-2/neu; HER2; MLN 19; NEU; NGL; TKR1
LocusID: 2064 Cytogenetic: 17q12 Domains: Recep_L_domain, pkinase, TyrKc, S_TKc, YLP, Furin-like, FU
Summary: This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized. [provided by RefSeq, Jul 2008].

Transcript Variant: This variant (1) encodes the longest isoform (a).

* Delivery time is an estimate in business days. Occasional delays may occur due to unforeseen complexities in the preparation of your construct. International customers may expect an additional 1-2 weeks in shipping

 

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