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Home TrueClone SOCS1 Clone

SOCS1 (NM_003745) Human cDNA Clone

Specifications Citations (1) Clones of Other Species Product Documents
SKU Description Price Availibility*  
SC111081 SOCS1 (untagged)-Human suppressor of cytokine signaling 1 (SOCS1) (10ug) NM_003745.1, 10ug $380 In Stock
TF81001 TurboFectin, High performance Transfection reagent (1ml/vial) $420 In Stock
TA306303 Rabbit Polyclonal SOCS1 Antibody, 100ug $325 In Stock
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OriGene Data
Vector:pCMV6-XL4 Insert Size: Restriction Site: NotI-NotI
Sequence Data: Fully Sequenced ORF          5' Read Nucleotide Sequence         
OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Product Components: The cDNA clone is shipped in a 2-D bar-coded Matrix tube as dried plasmid DNA. The package also includes 100 pmols of both the corresponding 5' and 3' vector primers in separate vials. Every lot of primer is tested to provide clean sequencing of OriGene TrueClones.
Protein Families: Stem cell relevant signaling - JAK/STAT signaling pathwayStem cell - PluripotencyDruggable Genome
Protein Pathways: Ubiquitin mediated proteolysisJak-STAT signaling pathwayInsulin signaling pathwayType II diabetes mellitus
Reference Data
RefSeq: NM_003745.1, NP_003736
RefSeq Size: 1216 RefSeq ORF: 636
Synonyms : CIS1; CISH1; JAB; SOCS-1; SSI-1; SSI1; TIP3
LocusID: 8651 Cytogenetic: 16p13.13 Domains: SH2, SOCS
Summary: This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by a subset of cytokines, including IL2, IL3 erythropoietin (EPO), CSF2/GM-CSF, and interferon (IFN)-gamma. The protein encoded by this gene functions downstream of cytokine receptors, and takes part in a negative feedback loop to attenuate cytokine signaling. Knockout studies in mice suggested the role of this gene as a modulator of IFN-gamma action, which is required for normal postnatal growth and survival. [provided by RefSeq, Jul


* Delivery time is an estimate in business days. Occasional delays may occur due to unforeseen complexities in the preparation of your construct. International customers may expect an additional 1-2 weeks in shipping

 

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