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Home TrueClone FZD6 Clone

FZD6 (NM_003506) Human cDNA Clone

Specifications Citations (2) Clones of Other Species Product Documents
SKU Description Price Availibility*  
SC316995 FZD6 (untagged)-Human frizzled family receptor 6 (FZD6), transcript variant 1 (10ug), NM_003506.2, 10ug $680 In Stock
TF81001 TurboFectin, High performance Transfection reagent (1ml/vial) $420 In Stock
TA310509 Rabbit Monoclonal antibody against Frizzled-6 (FZD6), 100ul $325 3-7 Days
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OriGene Data
Vector:pCMV6-XL4 Insert Size: Restriction Site: NotI-NotI
Sequence Data: Fully Sequenced ORF          5' Read Nucleotide Sequence          3' Read Nucleotide Sequence         
OTI Annotation: The open reading frame of this TrueClone was fully sequenced and found to be a perfect match to the protein associated to this reference.NA
OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Product Components: The cDNA clone is shipped in a 2-D bar-coded Matrix tube as dried plasmid DNA. The package also includes 100 pmols of both the corresponding 5' and 3' vector primers in separate vials. Every lot of primer is tested to provide clean sequencing of OriGene TrueClones.
Protein Families: GPCRTransmembraneDruggable Genome
Protein Pathways: Wnt signaling pathwayMelanogenesisPathways in cancerColorectal cancerBasal cell carcinoma
Reference Data
RefSeq: NM_003506.2, NP_003497
RefSeq Size: 3768 RefSeq ORF: 2121
Synonyms : FZ-6; FZ6; HFZ6; NDNC10
LocusID: 8323 Cytogenetic: 8q22.3 Domains: Fz, Frizzled
Summary: This gene represents a member of the 'frizzled' gene family, which encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The protein encoded by this family member contains a signal peptide, a cysteine-rich domain in the N-terminal extracellular region, and seven transmembrane domains, but unlike other family members, this protein does not contain a C-terminal PDZ domain-binding motif. This protein functions as a negative regulator of the canonical Wnt/beta-catenin signaling cascade, thereby inhibiting the processes that trigger oncogenic transformation, cell proliferation, and inhibition of apoptosis. Alternative splicing results in multiple transcript variants, some of which do not encode a protein with a predicted signal peptide.[provided by RefSeq, Aug 2011].

Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a). Both variants 1 and 2 encode the same isoform.

* Delivery time is an estimate in business days. Occasional delays may occur due to unforeseen complexities in the preparation of your construct. International customers may expect an additional 1-2 weeks in shipping

 

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