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Over 1000 citations of OriGene cDNA clones
c-Jun and Ets2 Proteins Regulate Expression of Spleen Tyrosine Kinase in T Cells J. Biol. Chem., Apr 2012; 287: 11833 - 11841. [JUND ]
CD16 Regulates TRIF-Dependent TLR4 Response in Human Monocytes and Their Subsets J. Immunol., Apr 2012; 188: 3584 - 3593. [FCGR3A ]
Constitutive Expression of Inter-a-inhibitor (IaI) Family Proteins and Tumor Necrosis Factor-stimulated Gene-6 (TSG-6) by Human Amniotic Membrane Epithelial and Stromal Cells Supporting Formation of the Heavy Chain-Hyaluronan (HC-HA) Complex J. Biol. Chem., Apr 2012; 287: 12433 - 12444. [TNFAIP6 ]
Developmental Endothelial Locus-1 (Del-1) Mediates Clearance of Platelet Microparticles by the Endothelium Circulation, Apr 2012; 125: 1664 - 1672. [EDIL3 ]
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RYK (NM_002958) Human Kinase Deficient Mutant

Specifications Clones of Other Species Product Manual FAQs
Cat. No. Ref. ID Description Amount Price Shipping  
SC323660 NM_002958 Kinase deficient mutant (K234M) of Homo sapiens RYK receptor-like tyrosine kinase (RYK), transcript variant 2 as transfection-ready DNA NM_002958.2 10ug $910 Next day Add to Shopping Cart
Click here for the corresponding wild type clone.
    
Click here to learn about OriGene’s recombinant RYK protein


OriGene Data
Vector:pCMV6-XL4 Insert Size: 3100 Restriction Site:
Sequence Data: 5' Read Nucleotide Sequence          Kinase domain sequence
OTI Annotation: This kinase-deficient mutant clone was generated by created by site-directed mutagenesis from the corresponding wild-type clone. See details in "Application of active and kinase-deficient kinome collection for identification of kinases regulating hedgehog signaling." Cell. 2008 May p536-548.
OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Product Components: The cDNA clone is shipped in a 2-D bar-coded Matrix tube as dried plasmid DNA. The package also includes 100 pmols of both the corresponding 5' and 3' vector primers in separate vials. Every lot of primer is tested to provide clean sequencing of OriGene TrueClones.
Protein Families: Protein KinaseTransmembraneDruggable Genome
Reference Data
RefSeq: NM_002958.2, NP_002949
 RefSeq Size: 2951 RefSeq ORF: 1824
Synonyms : D3S3195; JTK5; JTK5A; RYK1
LocusID: 6259 Cytogenetic: 3q22 Domains: pkinase, TyrKc, S_TKc, WIF
Summary: The protein encoded by this gene is an atypical member of the family of growth factor receptor protein tyrosine kinases, differing from other members at a number of conserved residues in the activation and nucleotide binding domains. This gene product belongs to a subfamily whose members do not appear to be regulated by phosphorylation in the activation segment. It has been suggested that mediation of biological activity by recruitment of a signaling-competent auxiliary protein may occur through an as yet uncharacterized mechanism. Two alternative splice variants have been identified, encoding distinct isoforms. [provided by RefSeq].

Transcript Variant: This variant (2) uses an alternate in-frame splice site in the coding region, compared to variant 1, resulting in a shorter protein (isoform 2).

Insert Size determined experimentally by digestion of the clone with Not I restriction enzyme

 

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