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Home TrueClone BMPR2 Clone

BMPR2 (NM_001204) Human cDNA Clone

Specifications Citations (1) Clones of Other Species Product Documents
SKU Description Price Availibility*  
SC108987 BMPR2 (untagged)-Human bone morphogenetic protein receptor, type II (serine/threonine kinase) (BMPR2) (10ug), NM_001204.5, 10ug $185 4 weeks
TF81001 TurboFectin, High performance Transfection reagent (1ml/vial) $420 In Stock
TA308587 Rabbit polyclonal antibody to BMPR2 (bone morphogenetic protein receptor, type II (serine/threonine kinase)), 100ul $325 In Stock
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Also for BMPR2 (NM_001204)
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OriGene Data
Vector:pCMV6-XL5 Insert Size: 3670 Restriction Site: NotI-NotI
Sequence Data: Fully Sequenced ORF          5' Read Nucleotide Sequence          3' Read Nucleotide Sequence         
OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Product Components: The cDNA clone is shipped in a 2-D bar-coded Matrix tube as dried plasmid DNA. The package also includes 100 pmols of both the corresponding 5' and 3' vector primers in separate vials. Every lot of primer is tested to provide clean sequencing of OriGene TrueClones.
Protein Families: Protein KinaseTransmembraneDruggable Genome
Protein Pathways: Cytokine-cytokine receptor interactionTGF-beta signaling pathway
Reference Data
RefSeq: NM_001204.5, NP_001195
RefSeq Size: 11449 RefSeq ORF: 3117
Synonyms : BMPR-II; BMPR3; BMR2; BRK-3; POVD1; PPH1; T-ALK
LocusID: 659 Cytogenetic: 2q33-q34 Domains: Activin_recp, pkinase, TyrKc, S_TKc
Summary: This gene encodes a member of the bone morphogenetic protein (BMP) receptor family of transmembrane serine/threonine kinases. The ligands of this receptor are BMPs, which are members of the TGF-beta superfamily. BMPs are involved in endochondral bone formation and embryogenesis. These proteins transduce their signals through the formation of heteromeric complexes of two different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding. Mutations in this gene have been associated with primary pulmonary hypertension, both familial and fenfluramine-associated, and with pulmonary venoocclusive disease. [provided by RefSeq, Jul 2008].

Transcript Variant: This variant (1) encodes the full length isoform. Isoform 1 is 508 aa longer than isoform 2 and includes a long cytoplasmic tail unique to this bone morphogenetic protein type II receptor.

* Delivery time is an estimate in business days. Occasional delays may occur due to unforeseen complexities in the preparation of your construct. International customers may expect an additional 1-2 weeks in shipping

 

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